Collecting and Storing Biological Samples From Patients With Ewing Sarcoma

Children's Oncology Group

Status: Completed

Conditions: Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Askin Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Treatments: Other: Laboratory Biomarker Analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT00899990

COG-AEWS07B1

U10CA098543 (U.S. NIH Grant/Contract)

NCI-2009-00370 (Registry Identifier)

AEWS07B1 (Other Identifier)

UG1CA189958 (U.S. NIH Grant/Contract)

CDR0000544202

Details and patient eligibility

About

This research study is collecting and storing samples of tumor tissue, bone marrow, and blood from patients with Ewing sarcoma. Collecting and storing samples of tumor tissue, bone marrow, and blood from patients with cancer to test in the laboratory may help the study of cancer in the future.

Full description

OBJECTIVES:

I. Collect biological specimens, including associated demographic and clinical data, from patients with Ewing sarcoma.

II. Provide a repository for long-term storage of Ewing sarcoma-related biological materials.

III. Make collected specimens available to qualified researchers to understand the biology of Ewing sarcoma and correlate these results with demographic and clinical data.

OUTLINE: This is a multicenter study.

Patients undergo collection of tumor specimens, bone marrow, and peripheral blood at diagnosis. Associated demographic and clinical data are collected and archived. Patients who are not enrolled on a therapeutic clinical trial are followed annually.

Enrollment: 908 patients

Sex: All

Ages: Under 21 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of Ewing sarcoma, including peripheral primitive neuroectodermal tumor and Askin tumor

  • Newly diagnosed or recurrent disease

Trial design

908 participants in 1 patient group

Observational (biomarker sampling)

Description:

Patients undergo collection of tumor specimens, bone marrow, and peripheral blood at diagnosis. Associated demographic and clinical data are collected and archived. Patients who are not enrolled on a therapeutic clinical trial are followed annually.

Treatment:

Other: Laboratory Biomarker Analysis