Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

Children's Oncology Group

Status: Completed

Conditions: Recurrent Childhood Medulloblastoma; Childhood Choroid Plexus Neoplasm; Childhood Atypical Teratoid/Rhabdoid Tumor; Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified; Recurrent Childhood Ependymoma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Visual Pathway Glioma; Childhood Supratentorial Ependymoma; Childhood Central Nervous System Germ Cell Tumor; Newly Diagnosed Childhood Ependymoma; Childhood Infratentorial Ependymoma; Childhood Grade III Meningioma; Recurrent Childhood Cerebral Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Grade I Meningioma; Childhood Craniopharyngioma; Childhood Cerebral Astrocytoma; Childhood Grade II Meningioma; Ependymoma; Childhood Oligodendroglioma

Treatments: Other: Cytology Specimen Collection Procedure

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT00919750

COG-ACNS02B3

NCI-2009-00334 (Registry Identifier)

ACNS02B3 (Other Identifier)

U10CA098543 (U.S. NIH Grant/Contract)

UG1CA189958 (U.S. NIH Grant/Contract)

CDR0000352347

Details and patient eligibility

About

The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Full description

OBJECTIVES:

I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions.

II. Provide a repository for long-term storage of specimens from these patients.

III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study.

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Enrollment: 1,258 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of brain tumor

• Previously treated at a Children?s Oncology Group (COG) institution

  • Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm

• Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission

Trial design

1,258 participants in 1 patient group

Ancillary-Correlative (tissue and blood sample collection)

Description:

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Treatment:

Other: Cytology Specimen Collection Procedure