Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma

Children's Oncology Group

Status: Completed

Conditions: Osteosarcoma

Treatments: Other: Cytology Specimen Collection Procedure

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT00899275

COG-AOST06B1

CDR0000562538

AOST06B1 (Other Identifier)

U10CA098543 (U.S. NIH Grant/Contract)

UG1CA189958 (U.S. NIH Grant/Contract)

NCI-2009-00410 (Registry Identifier)

Details and patient eligibility

About

The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Full description

OBJECTIVES:

I. To collect biological specimens from patients with osteosarcoma at Children?s Oncology Group (COG) institutions.

II. To provide a repository for long-term storage of osteosarcoma-related biological materials.

III. To make these specimens available to qualified researchers to understand the biology of osteosarcoma and correlate these results with the patients' clinical data.

OUTLINE:

After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.

Enrollment: 957 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• All osteosarcoma patients seen at COG institutions are eligible, including the following:

  • Newly diagnosed patients
  • Patients with recurrent disease who were not enrolled at the time of diagnosis

• The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required:

  • Paraffin embedded block OR 30 unstained slides
  • Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood
  • Fresh and frozen tumor specimens

• Patients are not required to enter a therapeutic study to enroll on this study

Trial design

957 participants in 1 patient group

Ancillary-correlative

Description:

After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.

Treatment:

Other: Cytology Specimen Collection Procedure