Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma

Children's Oncology Group

Status: Completed

Conditions: Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma

Treatments: Other: Laboratory Biomarker Analysis; Other: Cytology Specimen Collection Procedure

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT00897325

AALL05B1 (Other Identifier)

CDR0000491159

U10CA098543 (U.S. NIH Grant/Contract)

UG1CA189958 (U.S. NIH Grant/Contract)

COG-AALL05B1

NCI-2009-00310 (Registry Identifier)

Details and patient eligibility

About

This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.

Full description

OBJECTIVES:

I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.

II. Make these specimens available to qualified researchers to study the biology of ALL.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.

Patients are followed periodically for up to 10 years.

Enrollment: 811 patients

Sex: All

Ages: Under 30 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma

• In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or peripheral blood

• Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis of relapse

• No concurrent systemic antileukemic treatment administered for current relapse

  • Intrathecal chemotherapy allowed
  • On-therapy relapse allowed

Trial design

811 participants in 1 patient group

Ancillary-Correlative (Collecting and banking ALL specimens)

Description:

Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.

Treatment:

Other: Laboratory Biomarker Analysis

Other: Cytology Specimen Collection Procedure