Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer

Vanderbilt University Medical Center

Status: Completed

Conditions: Precancerous Condition; Hereditary Non-polyposis Colon Cancer; Colorectal Cancer

Treatments: Other: study of socioeconomic and demographic variables; Procedure: study of high risk factors; Procedure: evaluation of cancer risk factors

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00675636

VU-VICC-061182

CDR0000587344

VU-VICC-GI-0721

P30CA068485 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

RATIONALE: Gathering medical and family history information from patients and family members may help doctors better understand hereditary colorectal cancer and hereditary polyposis syndrome and identify patients at high risk of developing hereditary colorectal cancer.

PURPOSE: This research study is collecting information from patients and family members with hereditary colorectal cancer or polyposis syndrome or who are at high risk of developing hereditary colorectal cancer.

Full description

OBJECTIVES:

Primary

• To identify patients and their family members who have either hereditary colorectal cancer or polyposis syndrome or are at high risk for developing hereditary colorectal cancer.

Secondary

• To establish a tissue and data repository that will be used to further research in hereditary colorectal cancer syndromes.

OUTLINE: Data is collected on patients and their families for inclusion in a hereditary colorectal cancer registry. Registry data is entered into a secure database that includes information on patient demographics and medical and family cancer history. The information collected will be used to formulate screening and surveillance recommendations, to further knowledge of hereditary colorectal cancer, and to facilitate cancer research. Registry data will also be used to improve the quality of current standard of care through timely tracking and notification of patients for follow-up care, identification of registry participants at high risk for developing an inherited form of colon cancer, and by serving as a resource for future research.

Registry patients may undergo optional blood, urine, and/or sputum sample collection for inclusion in the tissue repository. Tissue samples from a previous biopsy may also be obtained. Samples will be stored for future research studies.

Enrollment: 730 patients

Sex: All

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Meets any of the following criteria:

  • Patients and family members with a known hereditary colorectal cancer or polyposis syndrome
  • Patients who meet Amsterdam I, II, or Bethesda criteria
  • Patients with a family history suggestive of a hereditary colorectal or polyposis syndrome
  • Patients diagnosed with colorectal cancer at < 50 years old

• Patients are identified through surgical, oncological, gynecological, and gastrointestinal programs, as well as outside referrals, self referral, and the Vanderbilit Tumor Registry

PATIENT CHARACTERISTICS:

• See Disease Characteristics

PRIOR CONCURRENT THERAPY:

• Not specified