Collection of Plasma Samples for Squamous Cell Carcinoma of the Head and Neck Patients

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Enrolling

Conditions: Squamous Cell Carcinoma of the Head and Neck

Treatments: Other: Plasma samples

Study type: Observational

Funder types: Other

Identifiers

NCT02139020

UCL-ONCO 2013-01

Details and patient eligibility

About

The investigators will collect plasma samples at baseline, during treatment, and at progression.

Full description

In this study, the investigators will collect plasma samples at baseline, during treatment, and at progression. This plasma bank will be used to study the potential value of some biomarkers to predict treatment activity or resistance to cetuximab or other targeted agents

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients treated with radiation therapy and cetuximab according to Bonner et al
• patients treated with cetuximab in combination with chemotherapy according to Vermorken et al.
• patients treated with a molecular targeted agent as a part of a clinical study

Exclusion criteria

• patients with another type of head and neck cancer
• patients non treated with targeted therapies

Trial design

400 participants in 1 patient group

No treatment

Description:

Patients with squamous cell carcinoma of the head and neck, targeted therapies, plasma samples: * Group 1 = patients treated with radiation therapy and cetuximab according to Bonner et al \[11\] * Group 2 = patients treated with cetuximab in combination with chemotherapy according to Vermorken et al. \[10\] * Group 3 = patients treated with a molecular targeted agent as a part of a clinical study

Treatment:

Other: Plasma samples