Cologne Placenta Cohort (CPC)

Sarah Appel

Status: Active, not recruiting

Conditions: Obesity, Maternal; Gestational Diabetes Mellitus in Pregnancy

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05424965

14-244

Details and patient eligibility

About

Aim of the study was to determine if signaling pathways in placentas of mothers affected by overweight/obesity or by gestational diabetes are altered compared to placentas of a control group (normal weight, no gestational diabetes). Moreover, maternal blood and umbilical cord blood were analysed.

Enrollment: 247 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• singleton pregnancy
• BMI before pregnancy >= 18
• with & without gestational diabetes
• c-section at gestational week 35+0 until 41+6

Exclusion criteria

• multiple pregnancy
• maternal serious internal disease
• infections before pregnancy (e.g. HIV, hepatitis B)
• pregnancy-associates diseases (e.g. gestoses, androgen insensitivity syndrome)

Trial design

247 participants in 6 patient groups

normal weight without gestational diabetes

Description:

BMI \< 25; normal glucose tolerance

Treatment:

Other: no intervention

normal weight with gestational diabetes

Description:

BMI \< 25; impaired oral glucose tolerance

Treatment:

Other: no intervention

overweight without gestational diabetes

Description:

BMI 25 - 29.9; normal glucose tolerance

Treatment:

Other: no intervention

overweight with gestational diabetes

Description:

BMI 25 - 29.9; impaired glucose tolerance

Treatment:

Other: no intervention

obese without gestational diabetes

Description:

BMI \>= 30; normal glucose tolerance

Treatment:

Other: no intervention

obese with gestational diabetes

Description:

BMI \>= 30; impaired glucose tolerance

Treatment:

Other: no intervention