Colonic Glucose vs. Saline Infusion

Shandong University

Status

Unknown

Conditions

Gastrointestinal Hormones

Treatments

Dietary Supplement: colonic infusion

Study type

Interventional

Funder types

Other

Identifiers

NCT05302206

2021-228

Details and patient eligibility

About

The distal ileum and proximal colon, where the glucagon-like peptide 1 (GLP-1) releasing cells predominate, are important organs in mediating glycemic control. The proximal colon is not easy to access and the correspond in vivo research remains to be difficult. The investigators intend to recruit subjects who underwent rectal surgery with simultaneous protective ileostomy and evaluate hormone secretion and glycemic excursions via ileostomy glucose or saline infusion, and quantify the glucose absorption rate within the proximal colon.

Enrollment

15 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and postmenopausal females aged 18 - 75 years
Body mass index (BMI) 20 - 35 kg/m2
With protective ileostomy due to benign or malignant rectal surgery

Exclusion criteria

History of postoperative adjuvant chemotherapy
Other significant illness, including epilepsy, cardiovascular or respiratory disease
Impaired renal or liver function (as assessed by calculated creatinine clearance < 90 mL/min or abnormal liver function tests (> 2 times upper limit of normal range))
Donation of blood within the previous 3 months
Participation in any other research studies within the previous 3 months
Females who are pre-menopausal
Inability to give informed consent
Vegetarians