Colonoscopy by Videocapsuls Versus Standard Colonoscopy. Intra-individual Comparison for the Subject With a Medium or High Risk of Colorectal Cancer.

Nantes University Hospital (NUH)

Status

Completed

Conditions

Colorectal Cancer

Treatments

Behavioral: diet and absorption of ColoPEG

Procedure: Colonoscopy with colic videocapsule

Procedure: Standard colonoscopy

Study type

Interventional

Funder types

Other

Identifiers

NCT00436514

BRD 06/12-L

Details and patient eligibility

About

Colorectal cancer is one of the most frequent and it prognosis is still serious. In France, diagnosis and screening applicated in numerous departements, and now in a path of generalization to the all country, is based on combination of searching blood into bowel movements (Haemoccult) for the screening of population with medium risk (age between 50 to 74 years old)and colonoscopy for the screening and diagnosis of pre-cancerous lesions for the patients with a high risk.Even if the efficiency of this strategy is proved, searching blood into the bowel movement by Haemoccult is still imperfect (a lot of false negative). Colonoscopy is not an ideal tool for screening. Indeed, its acceptability is not perfect and it constitute an invasive method, with complications, with a compulsory general anesthesia, implicating a high cost. The alternative of a screening method based on a non invasive method is required.

Enrollment

550 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age between 18 and 80 years
patient able to give his informed consent
No colorectal, intestinal inflammatory, ischemic or evolving infectious pathologies
No signs of stenosis of small intestine or colon
No contraindication to anesthesia
No participation to an other clinical study
Patient with and indication to colonoscopy for searching of a colorectal neoplasia during a screening program OR
Patient for who a endoscopic following is required because of familial cases or personal cases of polyps or colorectal cancer

Exclusion criteria

Presence of symptoms evocating an occlusive pathology
Recent complicated colic diverticulosis
No informed consent
pregnancy or no use of efficient contraception treatment
Patient with a pace-maker or others internal medical electronic device
Evolved nephric or cardiac insufficiencies
Hypersensibility to Fleet Phospho Soda (or one of the excipient), bisacodyl (or one of the excipient), motilium (or one of the excipient)
Presence of a prolactinoma