Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy

University of Sao Paulo

Status: Completed

Conditions: Graves' Ophthalmopathy; Graves' Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00697528

352/06

Details and patient eligibility

About

Orbital Venous flow study in patients with Grave's Orbitopathy in different manifestation forms and stages, made with Color Doppler Imaging

Full description

Prospective study with Grave's patients in active and fibrotic disease, myogenic and lipogenic forms, with muscle restriction and without muscle restriction and with or without optic compressive neuropathy. Blood flow was studied with Color Doppler Imaging (CDI) in the following orbital vessels:

• Superior Ophthalmic Vein (main target of the study protocol)
• Retinal Central Vein
• Retinal Central Artery
• Ophthalmic Artery

Enrollment: 66 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Grave's Orbitopathy with well defined disease.

Exclusion criteria

• Uncertain cases, with an undefined status of Grave's Ophthalmopathy.

Trial design

66 participants in 3 patient groups

Group control with healthy subjects

Description:

Healthy subjects without thyroid disease, ocular disease and previous surgery in the orbit or eye used in the study.

Graves' Ophthalmopathy - fibrotic phase

Description:

Patients that are clinically inactive (CAS equal or lower than 2). This group will be subdivided in the miogenic and lipogenic groups.

Graves' Ophthalmopathy - active phase

Description:

Patients that are clinically active, presenting a CAS of 4 or more points, with or without disthyroid optic neuropathy.