Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction

HaEmek Medical Center, Israel

Status: Completed

Conditions: Hyperthyroidism; Thyroid Dysfunction; Subclinical Hypothyroidism

Study type: Observational

Funder types: Other

Identifiers

NCT00437931

006-07-EMC

Details and patient eligibility

About

Overt hyperthyroidism and hypothyroidism are associated with inverted hemodynamic changes.Regional blood flow disturbances (including intrathyroidal) were also reported in these thyroid disorders. The purpose of this study is to investigate the thyroid vascularity and blood flow by Color Flow Doppler Sonography in patients with subclinical thyroid dysfunction

Full description

Color Flow Doppler Sonography (CFDS) has become in the last years an increasing procedure to assess the thyroid blood flow. Previous studies showed specific changes of thyroid blood flow in hyperthyroidism, Hashimoto's thyroiditis and thyroid nodules when investigated by CFDS. Subclinical hyperthyroidism and hypothyroidism are common laboratory findings, defined by normal thyroid hormones concentrations along with ,respectively,decreased or increase Thyroid stimulating hormone (TSH) level. We purpose to investigate thyroid vascularity by CFDS in patients with subclinical hyperthyroidism or hypothyroidism and compared them with euthyroid patients.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with subclinical hypothyroidism or hyperthyroidism
• patients with thyroid nodules and normal thyroid function

Exclusion criteria

• patients who are taking thyroxine, antithyroid drugs, lithium or amiodarone
• patients who had thyroid surgery or radioiodine therapy
• patients with NYHA class 3 or 4 heart failure

Trial design

60 participants in 3 patient groups

A

Description:

patients with subclinical hypothyroidism

B

Description:

patients with subclinical hyperthyroidism

C

Description:

patient with normal thyroid function.