Colorectal Cancer in Crohn's Disease

University of Rome Tor Vergata

Status: Unknown

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Colorectal Cancer

Treatments: Procedure: Total colectomy; Procedure: Segmental colectomy; Procedure: Total proctocolectomy

Study type: Observational

Funder types: Other

Identifiers

NCT04654494

REGISTROSPERIMENTAZIONI120/20

Details and patient eligibility

About

Retrospective multicentre study. All patients with a diagnosis of Crohn's disease (CD) and operated for colorectal cancer (CRC) between 01/01/2010 and 01/01/2020 will be included in the dataset.

Data will include preoperative, intraoperative and postoperative variables, with long term follow up when feasible.

The study will focus on a comparison between patients treated with total proctocolectomy (TPC) and patients treated with subtotal colectomy (STC) or segmental resection (SR).

Primary endpoints will be oncologic outcomes, postoperative morbidity and mortality. Secondary endpoints include quality of life (QoL).

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients with a diagnosis of Crohn's disease and concomitant primary colorectal cancer who underwent surgery in an expert centre between 01/01/2010 and 01/01/2020

Exclusion criteria

• Patients who underwent non-oncologic segmental resection will be excluded from outcome analysis.
• Patients with known genetic colorectal cancer syndromes (eg. Familial Adenomatous Polyposis, Hereditary Non-Polyposis ColoRectal Cancer Syndrome)

Trial design

70 participants in 1 patient group

Chron's disease patients with colorectal cancer

Description:

This group of patients with Chron's disease have been diagnosed with colorectal cancer and treated surgically

Treatment:

Procedure: Total colectomy

Procedure: Total proctocolectomy

Procedure: Segmental colectomy