Colour Vision Impairment During Acute Hypobaric Hypoxia

Universitätsklinikum Köln

Status: Completed

Conditions: Hypoxia, Altitude

Treatments: Other: Hypobaric Hypoxia

Study type: Interventional

Funder types: Other

Identifiers

NCT05584813

DRU-COLOR-KOELN

Details and patient eligibility

About

This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.

Full description

This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.

Five different Groups were analysed:

• ground control binocular (n=12, Bi/GC)
• ground control monocular (n=11, Mo/GC)
• 10,000 ft, 60 min, monocular (n=10, Mo/60/10,000)
• 15,000 ft, 15 min, binocular (n=11, Bi/15/15,000)
• 15,000 ft, 60 min, monocular (n=10, Mo/60/15,000)

Enrollment: 54 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• volunteers from 18 years old

Exclusion criteria

• cardiovascular, pulmonary, neurological, or ear, nose, and throat disease
• pregnant or suffering from cold symptoms

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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54 participants in 5 patient groups

ground control binocular

No Intervention group

Description:

Intervention: pressure chamber environment Procedures: Colour vision tests were performed under normoxia with both eyes three times in a row for appropriate comparability to the simulated flight stages pre-peri-post hypoxia in the intervention groups

ground control monocular

No Intervention group

Description:

Intervention: pressure chamber environment Procedures: Colour vision tests were performed under normoxia with one eye at a time three times in a row for appropriate comparability to the simulated flight stages pre-peri-post hypoxia in the intervention groups

10,000 ft, 60 min, monocular pre-peri-post

Experimental group

Description:

Intervention: Hypoxia equivalent to an altitude of 10.000 ft. for 60 minutes Procedures: Colour vision tests were performed with one eye at a time, thereby: * pre intervention with no hypoxia administered * during intervention with hypoxia equivalent to an altitude of 10.000 ft. for 60 minutes * post intervention with no hypoxia administered

Treatment:

Other: Hypobaric Hypoxia

15,000 ft, 15 min, binocular

Experimental group

Description:

Intervention: Hypoxia equivalent to an altitude of 15.000 ft. for 15 minutes Procedures: Colour vision tests were performed with both eyes, thereby: * pre intervention with no hypoxia administered * during intervention with hypoxia equivalent to an altitude of 15000 ft. for 15 minutes * post intervention with no hypoxia administered

Treatment:

Other: Hypobaric Hypoxia

15,000 ft, 60 min, monocular

Experimental group

Description:

Intervention: Hypoxia equivalent to an altitude of 15.000 ft. for 60 minutes Procedures: Colour vision tests were performed with one eye at a time, thereby: * pre intervention with no hypoxia administered * during intervention with hypoxia equivalent to an altitude of 15.000 ft. for 60 minutes * post intervention with no hypoxia administered

Treatment:

Other: Hypobaric Hypoxia