Combination Chemotherapy for 1st Line Treatment of Advanced or Metastatic Pancreatic Cancer

University of Oklahoma (OU)

Status and phase

Completed

Phase 2

Conditions

Metastatic Pancreatic Cancer

Treatments

Drug: bevacizumab

Drug: oxaliplatin

Drug: gemcitabine

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00222469

2004-0652

Details and patient eligibility

About

The purpose of this study is to find out if giving patients bevacizumab along with the chemotherapy drugs oxaliplatin and gemcitabine will improve overall survival.

In addition, the study will find out what side effects patients may have by taking bevacizumab, oxaliplatin, and gemcitabine together.

Full description

Design:

A phase II single arm study. All patients receive bevacizumab 10mg/kg and gemcitabine 1000mg/m2 on day 1 followed by oxaliplatin 100mg/m2 on day 2 of a 14 day cycle.

Purpose:

The purpose of this study is to find out if giving patients bevacizumab, along with the chemotherapy drugs oxaliplatin and gemcitabine, will improve overall survival. In addition, the study will find out what side effects patients may have by taking bevacizumab, oxaliplatin and gemcitabine together.

Enrollment:

Approximately 30 patients will be enrolled to the study between the University of Oklahoma and M.D. Anderson Cancer Center.

Duration:

The study will be conducted over approximately 2 years.

Enrollment

50 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age >/= 18 years old
ECOG performance status 0-2.
Patients with metastatic or unresectable locally advanced adenocarcinoma of the pancreas.
Patients who have recurrent disease post pancreaticoduodenectomy no earlier than 6 months after resection. Patients with recurrent disease who had completed adjuvant therapy in the form of radiation with or without radiosensitizing 5-fluorouracil (5-FU) 6 months prior to recurrence may be included.
Signed informed consent/authorization is obtained prior to conducting any study specific screening procedures.
No prior chemotherapy for advanced pancreatic cancer
Patient must have measurable disease
Use of effective means of contraception (men and women) in subjects of child-bearing potential
Obstructive jaundice must be relieved before inclusion
Adequate hepatic, renal, and bone marrow function: leukocytes >= 3,000/uL, absolute neutrophil count >= 1,500/uL, platelets >= 100,000/uL, total bilirubin < = 1.5 X institutional upper limits of normal (ULN), AST (SGOT)/ALT (SGPT) <= 2.5 X institutional ULN, creatinine <= 1.5 mg/dL

Exclusion criteria

Previous chemotherapy for pancreatic cancer.
Patients who have recurrent disease within 6 months after pancreaticoduodenectomy or had received adjuvant therapy within 6 months of disease recurrence.
Uncontrolled intercurrent illness including:
- Active infection
- Cardiovascular: New York Heart Association (NYHA) grade II or greater congestive heart failure, unstable angina pectoris, cardiac arrhythmias not well controlled with medication, myocardial infarction within the previous 6 months, blood pressure > 150/100 mmHg
- Clinically significant peripheral vascular disease
- History of stroke within previous 6 months
- Evidence of bleeding diathesis or coagulopathy
Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study.
Minor surgical procedures, fine needle aspirations or core biopsies within 7 days prior to Day 0
Urine protein:creatinine ratio > 1.0 at screening
History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior to Day 0
Serious, non-healing wound, ulcer, or bone fracture
Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurological dysfunction that would confound the evaluation of neurological and other adverse events. A computed tomography (CT) scan of the brain is not needed for eligibility and will be done only if the patient presents with symptoms suggestive of brain metastases.
Patients may not be receiving any other investigational agents, or have participated in any investigational drug study within 28 days preceding start of study treatment.
The teratogenic potential of this combination is currently unknown. Women who are pregnant or lactating are excluded.
History of any other malignancy in the last 5 years, except patients with a prior history of in situ cancer or basal or squamous cell skin cancer.
Peripheral neuropathy > grade 1
Psychiatric illness/social situations that would limit compliance with study requirements