Combination Chemotherapy in Treating Older Patients With Solid Tumour, (OLD)

GERCOR - Multidisciplinary Oncology Cooperative Group

Status and phase: Completed; Phase 4

Conditions: Solid Tumor Regardless of Localization and Stage

Treatments: Other: chemotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00664911

CDR0000593133

EudraCT-2007004103-36

GERCOR-OLD

Details and patient eligibility

About

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

PURPOSE: This clinical trial is studying how well combination chemotherapy works in treating older patients with solid tumour.

Full description

OBJECTIVES:

Primary

• To determine a prognostic scale of the feasibility of chemotherapy (at least two-thirds of the dose intensity usually administered) in patients aged 75 years or older with solid tumour.

Secondary

• To evaluate the efficacy, in terms of clinical and/or biological response, of treatments administered.
• To evaluate the incidence of severe (grade 3-4) toxicity.

OUTLINE: This is a multicenter study. Patients receive one of the following regimens according to cancer diagnosis and principal investigator preference. All regimens last 3 months.

Enrollment: 516 patients

Sex: All

Ages: 75+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed solid tumour regardless of localization or stage

PATIENT CHARACTERISTICS:

• > or = 75 years
• patient planned to receive > or = 2/3 of standard dose of the first cycle

PRIOR CONCURRENT THERAPY:

Chemonaive patient.

Trial design

516 participants in 1 patient group

Chemotherapy

Other group

Description:

chemotherapy regimen

Treatment:

Other: chemotherapy