Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma

Mount Vernon Cancer Centre at Mount Vernon Hospital

Status and phase

Unknown

Phase 3

Conditions

Lymphoma

Treatments

Drug: vincristine sulfate

Biological: bleomycin sulfate

Drug: ABVD regimen

Drug: doxorubicin hydrochloride

Drug: mechlorethamine hydrochloride

Drug: prednisone

Drug: Stanford V regimen

Drug: dacarbazine

Drug: vinblastine sulfate

Drug: etoposide

Radiation: radiation therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00041210

EU-20206

CDR0000069453

BNLI-STANFORDV

Details and patient eligibility

About

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating patients who have advanced Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of two different combination chemotherapy regimens in treating patients who have advanced Hodgkin's lymphoma.

Full description

OBJECTIVES:

Compare relapse-free and overall survival of patients with previously untreated advanced Hodgkin's lymphoma treated with bleomycin, doxorubicin, etoposide, mechlorethamine, vinblastine, vincristine, and prednisone (Stanford V) vs doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD).
Compare the toxicity of these regimens in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are randomized to 1 of 2 treatment arms.

Arm I (Stanford V): Patients receive mechlorethamine on weeks 1, 5, and 9; vinblastine and doxorubicin on weeks 1, 3, 5, 7, 9, and 11; etoposide IV over 30-45 minutes for 2 consecutive days on weeks 3, 7, and 11; and vincristine and bleomycin on weeks 2, 4, 6, 8, 10, and 12. Patients also receive oral prednisone every other day on days 1-63 followed by a taper on days 64-84. Treatment continues for 12 weeks.
Arm II (ABVD): Patients receive doxorubicin, bleomycin, vinblastine, and dacarbazine on days 1 and 15. Treatment repeats every 28 days for 6-8 courses.

All patients achieving a complete remission or partial remission after chemotherapy undergo involved field radiotherapy if they had initial bulky mediastinal disease, initial nodal masses at least 5 cm in diameter, or initial splenic disease.

Patients are followed every 3 months for 1 year, every 4 months for 1 year, every 6 months for 3 years, and then annually thereafter.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

PROJECTED ACCRUAL: Approximately 700-850 patients will be accrued for this study.

Enrollment

850 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Histologically confirmed Hodgkin's lymphoma (any sub-type)
- Stage IB, IIB, IIIA, IIIB, or IV OR
- Stage IA or IIA with locally extensive disease (e.g., bulky mediastinal disease (e.g., greater than 0.33 of the maximum transthoracic diameter on routine chest X-ray or at least 2 extranodal sites of disease))

PATIENT CHARACTERISTICS:

Age:

18 to 60

Performance status:

Not specified

Life expectancy:

Not specified

Hematopoietic:

Complete blood count normal unless directly due to Hodgkin's lymphoma

Hepatic:

Hepatic function normal unless directly due to Hodgkin's lymphoma

Renal:

Renal function normal unless directly due to Hodgkin's lymphoma

Cardiovascular:

No pre-existing cardiac disease

Pulmonary:

No pre-existing pulmonary disease

Other:

Not pregnant
Fertile patients must use effective contraception during and for six months after study
HIV negative
No other prior malignancy except basal cell or squamous cell skin cancer

PRIOR CONCURRENT THERAPY:

Biologic therapy: