Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy

Yonsei University

Status: Completed

Conditions: Thyroidectomy; Pain

Treatments: Drug: Propacetamol; Drug: Nefopam

Study type: Interventional

Funder types: Other

Identifiers

NCT02577068

4-2015-0746

Details and patient eligibility

About

Patients undergoing thyroidectomy are suffering not only surgical wound pain but posterior neck pain because of neck extension position during the surgery. However, there has been little attention of posterior neck pain. Nefopam and Propacetamol have different pharmacodynamics and been used for postoperative pain control in thyroidectomy patients. The aim of this study is evaluation of combination effect of Nefopam and Propacetamol for acute wound pain, posterior neck pain and chronic pain after thyroidectomy.

Enrollment: 84 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient who undergone open thyroidectomy
• 20~70 years old
• ASA I~III

Exclusion criteria

• hypersensitivity on Nefopam and Propacetamol
• Liver failure, chronic alcohol addiction
• severe hemolytic anemia, chronic nutrition deficiency
• history of seizure
• MI, MAO inhibitor
• pregnant, breast-feeding
• foreigners

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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84 participants in 3 patient groups

nefopam group

Active Comparator group

Treatment:

Drug: Nefopam

propacetamol group

Active Comparator group

Treatment:

Drug: Propacetamol

nefopam and propacetamol group

Experimental group

Treatment:

Drug: Propacetamol

Drug: Nefopam