Combination of Everolimus and Octreotide LAR in Aggressive Recurrent Meningiomas (CEVOREM)

Public Assistance-Hospitals of Marseille (AP-HM)

Status and phase

Completed

Phase 2

Conditions

Recurrent Meningiomas

Resistant Meningiomas

Treatments

Drug: Octreotide

Drug: Everolimus

Study type

Interventional

Funder types

Other

Identifiers

NCT02333565

RCAPHM14_0080 (Other Identifier)

2014-09

2014-003694-42 (EudraCT Number)

Details and patient eligibility

About

To determine if combination of everolimus and octreotide exert an anti-tumoral activity in recurrent and/or aggressive meningiomas growth with limited adverse effects.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and Female patients ≥ 18 years old with no maximum limited of age
Histologically proven meningioma grade II and III; grade I meningioma may also be included, if progression is documented (see criteria 3), particularly in case of skull base location
Progression is defined on 2 different MRI as an increase of meningioma's surface ≥ 5% by 3 months period (i.e. an increase of 5% over 3 months, 10% over 6 months, 15% over 9 months...) or as the apparition of a new unequivocal neurological symptom related to the meningioma. We considered as a new unequivocal neurological symptom a new occurring neurological symptom as, for instance, hemiparesia, oculomotor nerve palsy, visual loss, facial nerve palsy, facial neuralgia, directly related to meningioma and suggesting meningioma growth with increase of meningioma compression on neurological structures despite no increasing size on MRIs.
Patients must have failed surgery, and not amenable to a new curative intended surgery
Patients must have failed radiotherapy and/or radiosurgery
Prior chemotherapy is allowed, if progression under the cytotoxic agent is clearly documented. An interval of 4 weeks after the last administration of the cytotoxic agent is warranted. Number of prior chemotherapies is not limited.
Patients who have given their written consent
Patients affiliated to a social insurance regime
Adequate bone marrow function as shown by: Absolute Neutrophil Count ≥ 1.5 x 109/L,
Platelets ≥ 100 x 109/L, Hb >9 g/dL
Adequate liver function as shown by; serum bilirubin ≤ 1.5 x Upper Limit of Normal; International Normalized Ratio < 1.3; alanine aminotransferase and aspartate aminotransferase ≤ 2.5 x Upper Limit of Normal - Adequate renal function: serum creatinine ≤ 1.5 x Upper Limit of Normal - Fasting serum cholesterol ≤ 300 mg/dL OR ≤ 7.75 mmol/L and fasting triglycerides ≤ 2.5 x Upper Limit of Normal. NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after dyslipidemia treatment initiation.

Exclusion criteria

Patients with symptomatic lithiasis
Contra indication to octreotide and everolimus
Women of child-bearing age who are using no effective means of contraception
Pregnant or breast-feeding women or adults of reproductive potential who are not using effective birth control methods. If barrier contraceptives are being used, these must be continued throughout the trial by both sexes
Patients receiving other investigational agents or who received an investigative drug or therapy within the last 30 days.
Known intolerance or hypersensitivity to octreotide, everolimus or other rapamycin (sirolimus, temsirolimus)
Uncontrolled diabetes mellitus defined by HbA1c>8.5%
Patients who have any severe and/or uncontrolled medical condition:

unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction ≤ 6 months prior to inclusion, serious uncontrolled cardiac arrhythmia, active or uncontrolled severe infection, cirrhosis, chronic active hepatitis or chronic persistent hepatitis, severely impaired lung function (spirometry and Diffusing Capacity of the lung for carbon monoxide 50% or less of normal and O2 saturation 88% or less at rest on room air), active, bleeding diathesis

Patients receiving chronic treatment with immunosuppressive agent
Patients with a known history of HIV seropositivity
Patients who have a history of another primary malignancy ≤ 3 years, with the exceptions of non-melanoma skin cancer, and carcinoma in situ of uterine cervix.
Females patients who are pregnant or lactating, or are of childbearing potential and not practicing a medically acceptable method of birth control.