Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

University of Malaya

Status: Completed

Conditions: Tooth Extraction

Treatments: Combination Product: platelet-rich fibrin and calcium sulfate; Combination Product: platelet-rich fibrin and xenograft

Study type: Interventional

Funder types: Other

Identifiers

NCT03851289

DF RD 1621/0076 (L)

Details and patient eligibility

About

This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.

Full description

Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.

Enrollment: 10 patients

Sex: All

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• maxillary premolar teeth requiring extraction
• neighboring mesial and distal sound/restored teeth present
• alveolar bone level (measured from periapical radiographs) more than 50% of the root length
• age ranges from 25-55 years

Exclusion criteria

• bony fenestration of the socket wall confirmed from CBCT scan
• acute signs of infection
• periodontally compromised teeth
• absence of buccal plates
• any systemic disease which may hinder the healing process

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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10 participants in 2 patient groups

test (PRF-CS)

Experimental group

Description:

After atraumatic tooth extraction, the socket was gently curettage and irrigated with saline. Combination of platelet-rich fibrin and calcium sulfate was placed into the socket followed by a PRF plug . Black silk suture (3-0) was placed on mesial, mid and distal using simple interrupted technique.

Treatment:

Combination Product: platelet-rich fibrin and calcium sulfate

control (PRF-X)

Active Comparator group

Description:

After atraumatic tooth extraction, the socket was gently curettage and irrigated with saline. Combination of platelet-rich fibrin and xenograft (MinerOss® X) was placed into the socket followed by a PRF plug . Black silk suture (3-0) was placed on mesial, mid and distal using simple interrupted technique.

Treatment:

Combination Product: platelet-rich fibrin and xenograft