Combination of Platelets Rich Plasma and Hyaluronic is an Effective Tool for Treatment of Knee Osteoarthritis

University of Karachi

Status: Completed

Conditions: Knee Osteoarthristis

Treatments: Drug: Hyaluronic Acid (HA); Drug: Hyaluronic Acid (HA) and Platelet rich plasma; Drug: Platelet Rich Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT07089446

SCH-IRB-2022-05

Details and patient eligibility

About

The purpose of the study is to determine the effects of HA, PRP and the combination of HA and PRP in reducing pain and improving functional disability in patients with knee osteoarthritis.

Full description

To determine the effects of combination of platelet rich plasma (PRP) and hyaluronic acid and the PRP or HA alone in reducing pain and increasing range of motion among individuals with knee osteoarthritis.

Enrollment: 60 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• grade II-III according to the Kellgren-Lawrence classification),
• pain or functional limitations in patients' activity of daily living before the treatment,
• age between 40 and 70 years of age, and the absence of clinical or imaging signs of articular instability.

Exclusion criteria

• includes known hypersensitivity to hyaluronic acid,
• pregnancy and lactation, a BMI greater than 40 kg/m2,
• chronic administration of anticoagulant drugs or a history of coagulopathies,
• neoplastic lesions, and knee or kidney failures

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Group A

Experimental group

Description:

Hyaluronic acid

Treatment:

Drug: Hyaluronic Acid (HA)

Group B

Active Comparator group

Description:

platelet rich plasma

Treatment:

Drug: Platelet Rich Plasma

Group C

Other group

Description:

Hyaluronic acid and platelet rich plasma

Treatment:

Drug: Hyaluronic Acid (HA) and Platelet rich plasma