Combination of Remifentanil and Flurbiprofen in Sedation and Analgesia for ESWL of Pancreatic Stone

Naval Military Medical University

Status and phase: Completed; Phase 4

Conditions: Pancreatic Stone Disease

Treatments: Drug: Remifentanil; Drug: Flurbiprofen and remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01998217

Rem-ESWL-Pancreas

Details and patient eligibility

About

Extracorporeal shock wave lithotripsy (ESWL) of pancreatic stones has been described as an effective approach for stone drainage and pain relief, and general or epidural anesthesia has been reported for such procedure. Single infusion of remifentanil has been described in ESWL of urinary stones, but it has never been described in ESWL of pancreatic stones. Moreover, single infusion of remifentanil might induce several complications, such as postoperative nausea and vomiting. The investigators attended to investigated whether combination of flurbiprofen with remifentanil reduced remifentanil dose and attenuated the complications.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged 18-65 years
• ASA I-II
• ESWL indication was met

Exclusion criteria

• patients with hypertension
• patients compromised in cardiopulmonary function
• patients undergoing ESWL for the second or more times

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Rem group

Active Comparator group

Description:

Patients in this group receive single infusion of remifentanil with target concentration infusion.

Treatment:

Drug: Remifentanil

Flur group

Experimental group

Description:

Patients in this group receive both infusion of flurbiprofen and remifentanil

Treatment:

Drug: Flurbiprofen and remifentanil