Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets

Sharif Medical Research Center

Status

Enrolling

Conditions

Tooth Extraction

Treatments

Other: Diode Laser 980 nm.

Study type

Interventional

Funder types

Other

Identifiers

NCT06552936

SMDC/SMRC/242-22

Details and patient eligibility

About

The goal of this clinical trial is to learn if the laser works to improve wound healing and bone regeneration after tooth extraction. The main question it aims to answer is:

Does laser therapy improve wound healing and bone regeneration after tooth extraction?

Researchers will compare a laser to sham laser therapy to see if the laser enhances wound healing and bone regeneration.

Participants will:

Have exposure to laser or sham laser therapy immediately after tooth extraction Record their pain intensity on days 2, 4, 6 and 14 Visit the clinic after 10 days for follow-up Again, visit the clinic after 4 months for evaluation

Enrollment

44 estimated patients

Sex

All

Ages

21+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

At least 21 years old, regardless of gender
Non-traumatic tooth extraction of the lower jaw is indicated
Willing for dental implant surgery
Dental appointments are available at the study place
Absence of active infection at the extraction site
Signed informed permission is provided.

Exclusion criteria

Pregnant, lactating, and menopausal women
Smokers
Those having head and neck radiotherapy
Those with any sort of acute infection (e.g., periodontal abscess), immune deficiency, or metabolic conditions such as diabetes mellitus and osteoporosis
Patients will also be eliminated if they have a complication during surgery, such as bleeding or operational difficulties, or if the procedure takes longer than 90 minutes.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

44 participants in 4 patient groups

Low level laser therapy (LLLT)

Experimental group

Description:

The LLLT phase will be done with an uninitiated 300-micron tip at 0.5 W in a CW. For this phase, the tip will be kept apart from the targeted tissue by 1mm in the scanning motion.

Treatment:

Other: Diode Laser 980 nm.

High intensity laser therapy (HILT)

Experimental group

Description:

HILT will be done directly after extraction when the extraction socket is filled with blood (without oozing). It will be conducted with the help of an un-initiated 300-micron tip running at the 2-watt (W) power output. It will be in a continuous emission mode (CW).

Treatment:

Other: Diode Laser 980 nm.

Low level laser therapy+ high intensity laser therapy

Experimental group

Description:

The patient will receive a combination of LLLT and HILT.

Treatment:

Other: Diode Laser 980 nm.

Control

Sham Comparator group

Description:

The patient will have the identical treatment as the experimental group but with the laser device in the non-activated phase.