Combination Therapy for Patients With Untreated Metastatic Pancreatic Ductal Adenocarcinoma

HonorHealth Research Institute

Status and phase

Active, not recruiting

Phase 2

Conditions

Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Treatments

Drug: Albumin-bound paclitaxel

Drug: Paricalcitol

Drug: Cisplatin

Drug: Nivolumab

Drug: Gemcitabine

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02754726

NAPPCG-EB 2015-001

Details and patient eligibility

About

The purpose of this study is to find out if the study drugs nivolumab, albumin- bound paclitaxel, paricalcitol, cisplatin, and gemcitabine given together are safe and effective when combined to treat advanced pancreatic cancer.

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 years of age .
Histologically or cytologically confirmed metastatic pancreatic ductal adenocarcinoma.
Capable of providing informed consent and complying with Trial procedures.
Karnofsky Performance Status (KPS) of ≥ 70%.
Life expectancy ≥ 12 weeks.
Measurable tumor lesions according to RECIST 1.1 criteria.
Women must not be able to become pregnant (e.g. post-menopausal for at least 1 year, surgically sterile, or practicing adequate birth control methods) for the duration of the study. Women of child bearing potential must have a negative serum or urine pregnancy test at the Screening Visit and be non-lactating. Both male and female patients of reproductive potential must agree to use a reliable method of birth control during the study.

Exclusion criteria

Patients must have received no previous radiotherapy, surgery, chemotherapy or investigational therapy for the treatment of metastatic disease. Prior treatments in the adjuvant setting with gemcitabine and/or 5-FU or gemcitabine administered as a radiation sensitizer are allowed, provided at least 6 months have elapsed since completion of the last dose and no lingering toxicities are present.
Palliative surgery and/or radiation treatment less than 4 weeks prior to initiation of study treatment.
Exposure to any investigational agent within 4 weeks prior to initiation of study treatment.
Evidence of central nervous system (CNS) metastasis (negative imaging study, if clinically indicated, within 4 weeks of Screening Visit).
History of other malignancies (except cured basal cell carcinoma, superficial bladder cancer or carcinoma in situ of the cervix) unless documented free of cancer for ≥5 years.
Laboratory values: Screening serum creatinine > upper limit of normal (ULN); total bilirubin > (ULN); alanine aminotransferase (ALT) and AST ≥ 2.5 ULN or ≥ 5.0×ULN if liver metastases are present; absolute neutrophil count <1,500/mm3, platelet concentration <100,000/mm3, hematocrit level <27% for females or <30% for males, or coagulation tests (prothrombin time [PT], partial thromboplastin time [PTT], International Normalized Ratio [INR]) >1.5×ULN unless on therapeutic doses of warfarin.
Current, serious, clinically significant cardiac arrhythmias as determined by the investigator.
History of HIV infection or active or chronic hepatitis B or C.
Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals.
Major surgery within 4 weeks prior to initiation of study treatment.
Any condition that might interfere with the patient's participation in the study or in the evaluation of the study results.
Any condition that is unstable and could jeopardize the patient's participation in the study.
Patient has a transplanted organ.
Patients with a history of autoimmune disease.
Prior PD-1 or PD-L1 therapy.
Patients taking any chemo or immunosuppressive steroids (equivalent to > 20 mg hydrocortisone per day).
Patients cannot have > Grade 1 pre-existing peripheral neuropathy (per CTCAE).