Combination Trial of Intravenous Paracetamol - Morphine for Treating Acute Renal Colic in Emergency Setting: An Optimum Treatment

Akdeniz University

Status and phase: Completed; Phase 4

Conditions: Renal Colic

Treatments: Drug: Paracetamol+Morphine; Drug: Placebo plus Morphine; Drug: Dexketoprofen plus Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT03865004

firatbektas

Details and patient eligibility

About

This randomized, placebo-controlled trial evaluated the analgesic efficacy and safety of intravenous morphine-paracetamol combination and morphine-dexketoprofen combination morphine for the optimum treatment of renal colic. Combination of IV morphine and paracetamol is as effective and rapid as combination of IV Morphine and IV dexketoprophen for optimum treating of renal colic.

Enrollment: 136 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Renal colic patients -

Exclusion Criteria: Not renal colic patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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136 participants in 3 patient groups, including a placebo group

Placebo

Placebo Comparator group

Treatment:

Drug: Dexketoprofen plus Morphine

Drug: Placebo plus Morphine

Drug: Paracetamol+Morphine

Paracetamol

Active Comparator group

Treatment:

Drug: Dexketoprofen plus Morphine

Drug: Placebo plus Morphine

Drug: Paracetamol+Morphine

Dexketoprofene

Active Comparator group

Treatment:

Drug: Dexketoprofen plus Morphine

Drug: Placebo plus Morphine

Drug: Paracetamol+Morphine