Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients (TregCMRRS)

Capital Medical University

Status: Unknown

Conditions: Reperfusion Injury, Myocardial; STEMI - ST Elevation Myocardial Infarction

Treatments: Other: Treg levels and CMR results

Study type: Observational

Funder types: Other

Identifiers

NCT03939338

BFH-Treg and CMR

Details and patient eligibility

About

This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).

Enrollment: 250 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed STEMI diagnosis
• Undergoing primary percutaneous coronary intervention (presenting <12 hours after symptom onset)
• Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckle tracking imaging echocardiogram (STE) examinations
• Patients agreed and provided informed consent

Exclusion criteria

• Previous myocardial infarction or revascularization (PCI or CABG)
• Congestive heart failure with LVEF<40%
• Atrial fibrillation
• Renal insufficiency (GFR < 30 ml/min/1.73m^2)
• Acute infectious diseases within nearly 3 months
• Rheumatic immune system diseases
• Malignant tumors
• Claustrophobia
• Contraindicated to CMR
• Patients do not agree to be included in the study

Trial design

250 participants in 1 patient group

Participates

Treatment:

Other: Treg levels and CMR results