Combinatorial Therapy to Induce an HIV Remission

University of California San Francisco (UCSF)

Status and phase

Active, not recruiting

Phase 2

Phase 1

Conditions

HIV/AIDS

Treatments

Drug: Combination Intervention

Study type

Interventional

Funder types

Other

NETWORK

Industry

NIH

Identifiers

NCT04357821

18-26957

Details and patient eligibility

About

Combination approaches will almost certainly be required to generate durable control of HIV in the absence of antiretroviral therapy (a "remission"). In this study, 20 individuals will receive a combination regimen administered during ART and then undergo an analytic treatment interruption (ATI).

Full description

The investigators will perform a single arm study of twenty individuals with HIV infection on effective ART. All participants will receive a combination regimen administered during ART and then undergo an analytic treatment interruption. Our strategy has five stages

IL-12 adjuvanted p24CE DNA prime (p24CE/IL-12) at Weeks 0 and 4
IL-12 adjuvanted DNA boost (p24CE plus p55gag) at Week 12
MVA/HIV62B (MVA62B) boost at Week 20
single dose of two bNAbs (VRC07-523LS and 10-1074, which target CD4 binding site and V3 loop, respectively) at week 24 with a TLR9 agonist (lefitolimod) administered weekly between Weeks 24 and 33 (10 doses)
ATI with single dose of VRC07 and 10-1074 at Week 34

Follow-up off ART will occur through at least Week 46 (expected) and on or off ART (depending on outcome) through Week 86.

Should this approach work, viral load would be expected to rebound in all individuals a few weeks after the bNAb levels decrease to sub-therapeutic levels. This acute rebound would be followed by a new lower viral load set-point and perhaps a long-term remission.

Enrollment

11 patients

Sex

All

Ages

18 to 67 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Key Inclusion Criteria

Willing and able to provide written informed consent.
Age ≤67 years at the time of enrollment for those who started treatment during early infection and <65 years for those who started treatment during chronic infection.
Documented HIV-1 infection.
On continuous antiretroviral therapy for at least 12 months without any interruptions of greater than 14 consecutive days within the last 1 year, and on a stable regimen that does not include an non-nucleoside reverse transcriptase inhibitor (NNRTI) for at least 4 weeks, without plans to modify ART during the study period.
Screening plasma HIV RNA levels below the level of quantification on all available determinations in past 24 months.
Screening CD4+ T-cell count ≥ 500 cells/mm3.

Key Exclusion Criteria

Subjects receiving a non-nucleoside reverse transcriptase inhibitor
Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
High-level resistance to both 10-1074 and VRC-07 as defined using the PhenoSense Neutralizing Antibody Assay (Monogram Biosciences).
Any history of an HIV-associated malignancy, including Kaposi's sarcoma and any type of lymphoma, or virus-associated cancers.
Active or recent non-HIV-associated malignancy requiring systemic chemotherapy or surgery in the preceding 36 months or for whom such therapies are expected in the subsequent 12 months.
CD4+ T cell nadir <350 cells/mm3 during the chronic phase of infection (beginning 6 months following the estimated infection date and confirmed on repeat testing).
Active hepatitis B (HBV) infection defined as positive HBV surface antigen test.
Active hepatitis C (HCV) infection. 10. Presence of significant abnormalities on electrocardiogram. 11. History of potential immune-mediated medical conditions. Individuals with isolated Raynaud's phenomenon or localized disease requiring topical therapy alone will not be excluded.