Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation

Minia University

Status: Completed

Conditions: Corneal Perforation

Treatments: Procedure: Platelet rich plasma clot implantation; Procedure: Wound closure with amniotic membrane

Study type: Interventional

Funder types: Other

Identifiers

NCT03500796

56-2/2018

Details and patient eligibility

About

Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation

Full description

Use of amniotic membrane and platelet rich plasma clot for closure of central corneal perforation either post infective or posttraumatic

Enrollment: 10 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• central corneal perforation

Exclusion criteria

• active infection
• posterior segment pathology
• non seeing eye

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Corneal perforation patients

Other group

Description:

Patients who had/impeding corneal perforation due to melting of the cornea after infection with a corneal pathogen (bacterial or viral), with no previous surgical intervention. Patients will undergo: Platelet rich plasma clot implantation Wound closure with amniotic membrane

Treatment:

Procedure: Wound closure with amniotic membrane

Procedure: Platelet rich plasma clot implantation