Combined Cataract Surgery and Planned Descemetorhexis

Medical College of Wisconsin

Status: Completed

Conditions: Fuchs' Corneal Dystrophy; Cataract

Treatments: Procedure: Descemetorhexis

Study type: Interventional

Funder types: Other

Identifiers

NCT02206594

MCW-EI-001

Details and patient eligibility

About

A pilot study designed to assess the feasibility of planned descemetorhexis for the treatment of Fuchs' corneal dystrophy.

Enrollment: 2 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

General Inclusion Criteria:

• Patient >18 years old
• Willing and able to provide informed consent

Ocular Inclusion Criteria (all ocular inclusion criteria apply only to the study eye):

• Fuchs' corneal dystrophy diagnosed
• Cataract present
• Best corrected visual acuity ≤ 20/40
• Candidate for current endothelial transplant procedure (DSAEK, DMEK)

General Exclusion Criteria:

• <18 years old
• Medically unstable patient
• Monocular patient
• Unwilling or unable to provide informed consent

Ocular Exclusion Criteria (all ocular exclusion criteria apply only to the study eye):

• Corneal dystrophy other than Fuchs'
• Central corneal scar or central opacity not related to Fuchs'
• Severe nonproliferative diabetic retinopathy or proliferative diabetic retinopathy
• History of prior vitreoretinal surgery
• Advanced or unstable glaucoma
• Known steroid responders with glaucoma

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

2 participants in 1 patient group

Descemetorhexis

Experimental group

Treatment:

Procedure: Descemetorhexis