Combined CO2 Fractional Laser With Bimatoprost 0.03% Treatment of Alopecia Areata

Ahmed Hassan Nouh MD

Status and phase: Completed; Phase 2; Phase 1

Conditions: Alopecia Areata

Treatments: Device: CO2 fractional laser; Drug: Bimatoprost 0.03% solution

Study type: Interventional

Funder types: Other

Identifiers

NCT05600673

AlAzharUE

Details and patient eligibility

About

The goal of this study is to evaluate the efficacy and safety of combined CO2 fractional laser with Bimatoprost 0.03% as novel treatment of alopecia areata.

The main question to study is will the bimatoprost facilitate hair growth if added to fractional CO2 laser treatment in Alopecia areata.

Full description

The study included 30 patients who were diagnosed clinically and dermoscopically as alopecia areata with age ranged between 16-55 years. The patients are divided into 2 groups: Group I, received fractional laser sessions with immediate and daily Bimatoprost application and Group II, received only frequent Laser sessions. Laser sessions were given to each patch once every 3 weeks, the procedure was repeated for 3 times.

Enrollment: 30 patients

Sex: All

Ages: 16 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with alopecia areata of the scalp (multilocuolaris or single patch).
• Patient aged from 16- 55 years old in both sex.
• Other treatment wash out period is two months.

Exclusion criteria

• Ophiasis pattern and other patterns of alopecia areata.
• Chronic diseases of liver, heart, kidney and blood
• Pregnant women
• Infections of skin in site of intervention

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Bimatoprost + CO2

Experimental group

Description:

Each patient received three CO2 fractional laser sessions 3 weeks apart with immediate and subsequent daily Bimatoprost 0.03%,1 drop for each 1cm².

Treatment:

Drug: Bimatoprost 0.03% solution

Device: CO2 fractional laser

CO2

Active Comparator group

Description:

Each patient received only three CO2 fractional laser sessions 3 weeks apart

Treatment:

Device: CO2 fractional laser