Combined Dexmedetomidine and Glycopyrrolate Therapy

Kangbuk Samsung Hospital

Status: Withdrawn

Conditions: Bladder Irritable

Treatments: Drug: Dexmedetomidine; Drug: Glycopyrrolate + dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT05013320

DEXLYCO

Details and patient eligibility

About

Catheter-related bladder discomfort after transurethral resection of bladder tumor is frequent because of indwelling urinary catheter for irrigation. The mechanism of the catheter-related bladder discomfort is similar to that of overactive bladder, in which muscarinic acetylcholine receptors are stimulated. The catheter-related bladder discomfort is a well known predisposing factor for emergence delirium after general anesthesia. In this study, we aimed to compare the incidence of catheter-related bladder discomfort between dexmedetomidine only therapy and combind dexmedetomidine and glycopyrrolate therapy.

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status I and II
• elective transurethral resection of bladder tumor under general anesthesia

Exclusion criteria

• arrhythmia
• bladder outflow obstruction
• overacitve bladder
• end stage renal disease
• neurogenic bladder
• morbid obesity
• psychiatric disorder

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups

Dexmedetomidine only

Active Comparator group

Description:

dexmedetomidine is administered during the surgery

Treatment:

Drug: Dexmedetomidine

Combined dexmedetomidine and glycopyrrolate

Experimental group

Description:

glycopyrrolate and dexmedetomidine are administered during the surgery

Treatment:

Drug: Glycopyrrolate + dexmedetomidine