Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat

Seoul National University

Status: Unknown

Conditions: Pharyngitis

Treatments: Drug: Dexamethasone; Drug: Paracetamol

Study type: Interventional

Funder types: Other

Identifiers

NCT02252419

SoreThroatParacetamol

Details and patient eligibility

About

The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

Full description

The postoperative sore throat is a common complication after the general anesthesia which decreases the quality of life. Dexamethasone is known to effective for the prevention of postoperative sore throat. The combined effect of the dexamethasone and paracetamol for postoperative sore throat, however, is not investigated.

The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

Enrollment: 242 estimated patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for urologic surgery under general anesthesia
• ASA I-III

Exclusion criteria

• Patients with recent sore throat
• Patients with neck surgery
• Patients with anticipated difficult airway
• Patients with Mallampati grade 3
• Patients with severe cardiovascular or pulmonary disease
• Patients with allergic history to dexamethasone or paracetamol
• Patients with liver function disorder
• Patients with liver disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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242 participants in 2 patient groups

Dexamethasone

Active Comparator group

Description:

Dexamethasone will be administered 30 minutes before the anesthetic induction.

Treatment:

Drug: Dexamethasone

Dexamethasone+ Paracetamol (DP)

Experimental group

Description:

Dexamethasone will be administered 30 minutes before the anesthetic induction. Paracetamol will be administered at the end of the surgery.

Treatment:

Drug: Paracetamol

Drug: Dexamethasone