Combined Effect of tDCS and Motor or Cognitive Activity in Patients With Alzheimer's Disease

University of Verona

Status: Terminated

Conditions: Alzheimer Disease (AD)

Treatments: Device: Anodal tDCS; Device: Sham tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT06619795

140158

Details and patient eligibility

About

The goal of this clinical trial is to evaluate the effectiveness of combining tDCS with motor or cognitive activities on cognitive functions in patients with AD. Second aim is to investigate if tDCS has a different impact if it is combined with motor or cognitive activities.

Enrollment: 23 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mini Mental State Examination (MMSE) major or equal to 15;
• good level of compliance;
• acetylcholinesterase inhibitor treatment (e.g., donepezil, rivastigmine);
• no modifications of medication during the last four months.

Exclusion criteria

• behavioral disorders (e.g., aggressiveness);
• alcohol abuse;
• orthopedic pathology with risk of falls to the ground;
• respiratory pathology;
• severe auditory or visual deficits uncorrected;
• history of epileptic fits;
• anti-epileptic medication;
• metallic body implants; pacemaker;
• psychiatric, neurologic, systemic or metabolic disorders.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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23 participants in 4 patient groups

CogS

Sham Comparator group

Description:

The participants underwent cognitive treatment while receiving sham tDCS stimulation.

Treatment:

Device: Sham tDCS

MotS

Sham Comparator group

Description:

The participants underwent motor treatment while receiving sham tDCS stimulation

Treatment:

Device: Sham tDCS

CogA

Experimental group

Description:

The participants underwent cognitive treatment while simultaneously receiving anodal stimulation with tDCS.

Treatment:

Device: Anodal tDCS

MotA

Experimental group

Description:

The participants underwent motor treatment while simultaneously receiving anodal stimulation with tDCS.

Treatment:

Device: Anodal tDCS