Combined Effects of Transcranial Direct Current Stimulation on Postural Control in Elderly

Riphah International University

Status: Completed

Conditions: Postural; Defect

Treatments: Device: M1 Stimulation Group; Combination Product: M1 + Cerebellar Stimulation Group; Device: Sham Stimulation Group; Device: Cerebellar Stimulation Group (CbSG)

Study type: Interventional

Funder types: Other

Identifiers

NCT06757088

Summaiya Ishtiaq/01899

Details and patient eligibility

About

The current study aims to determine the effects of combination stimulation (M1 Cortex+ Cerebellum) along with balance training (X-box with Kinect) on postural control in elderly population and to compare the combined stimulation (M1+CbS) with individual motor cortex, cerebellar or sham stimulation.

Full description

The current study has been designed to investigate the potential effects of short term transcranial direct current stimulation on motor cortex and cerebellum both simultaneously and to document any additional benefits over each individual stimulations (M1 cortex stimulation, cerebellar stimulation or sham stimulation). Patients will be receiving the transcranial direct current stimulation combined with non-immersive virtual reality using Xbox 360 with Kinect in each group.

Enrollment: 52 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both genders
• Healthy elderly patients
• Age group of ≥ 60 years
• Fluent in reading and speaking Urdu language

Exclusion criteria

• Patients who have any congenital/Acquired walking or standing difficulty due to certain circumstances won't be included in the healthy adults group.
• Patients with Osteo-Arthritis (OA)
• Patients with cerebellar issues or issues such as vertigo with standing and walking etc.
• Individuals who had significant dysarthria or aphasia that might impair understanding of speech or verbal instruction
• Cognitive/communication impairment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 4 patient groups

M1 Stimulation Group (MSG)

Active Comparator group

Description:

For M1, the anodal electrode will be placed over M1 region while the cathodal electrode will be placed over the right contralateral supraorbital region.

Treatment:

Device: M1 Stimulation Group

Cerebellar Stimulation Group (CbSG)

Other group

Description:

For the CbSG, active anodal electrode will be placed over the cerebellum bilaterally about 1-2 cm below inion occipital protuberance, whereas the returning cathodal electrode will be placed on right buccinator muscle

Treatment:

Device: Cerebellar Stimulation Group (CbSG)

M1 + cerebellar stimulation group

Experimental group

Description:

In M1, the anodal electrode will be placed over the M1 region while the cathodal electrode will be placed over the right contralateral supraorbital region whereas simultaneously for the CbSG, active anodal electrode will be placed over the cerebellum bilaterally about 1-2 cm below inion occipital protuberance, whereas the returning cathodal electrode will be placed on right buccinator muscle

Treatment:

Combination Product: M1 + Cerebellar Stimulation Group

Sham Stimulation group (SSG)

Sham Comparator group

Description:

In Sham stimulation, Electrodes will be placed according to M1 Stimulation i.e., the anodal electrode will be placed over M1 region while the cathodal electrode will be placed over the right contralateral supraorbital region.

Treatment:

Device: Sham Stimulation Group