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Combined Epidural Morphine and Midazolam on Postoperative Pain

A

Assiut University

Status and phase

Unknown
Phase 2
Phase 1

Conditions

Acute Postoperative Pain

Treatments

Drug: midazolam

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

this study aim to Compare the effect of preoperative Epidural Midazolam, Morphine and their combination in postoperative pain relief and total morphine consumption.

Full description

Major abdominal surgeries with abdominal incisions lead to severe abdominal pain, which if treated inadequately, can cause shallow breathing, atelectasis, retention of secretions and lack of cooperation in physiotherapy. This increases the incidence of post-operative morbidity and leads to delayed recovery.Epidural anesthesia is safe and inexpensive technique with the advantage of providing surgical anesthesia and prolonged postoperative pain relief. It also an effective treatment of operative pain blunts autonomic, somatic and endocrine responses. Morphine and midazolam can be used as adjuvant to bupivicain to reduced the postoperative pain

Enrollment

20 estimated patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ASA I-II patients scheduled for major abdominal cancer surgeries

Exclusion criteria

  • patients with known allergy to the study drugs,
  • significant cardiac, respiratory, renal or hepatic disease,
  • drug or alcohol abuse,
  • psychiatric illness that would interfere with perception and assessment of pain.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

20 participants in 3 patient groups

MI
Active Comparator group
Description:
Bupivacaine 0.25% + midazolam 5mg in total volume 10m1
Treatment:
Drug: midazolam
MM
Active Comparator group
Description:
Bupivacaine 0.25% + midazolam 5mg and morphine 5mg in total volume 10ml
Treatment:
Drug: midazolam
MO
Active Comparator group
Description:
bupivacaine 0.25% + morphine 5 mg in total volume 10 ml
Treatment:
Drug: midazolam

Trial contacts and locations

1

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Central trial contact

Shereen M Kamal, Associate proferssor; Khaled M Fares, proferssor

Data sourced from clinicaltrials.gov

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