Combined Epidural Morphine and Midazolam on Postoperative Pain

Assiut University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Acute Postoperative Pain

Treatments: Drug: midazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT04033471

464

Details and patient eligibility

About

this study aim to Compare the effect of preoperative Epidural Midazolam, Morphine and their combination in postoperative pain relief and total morphine consumption.

Full description

Major abdominal surgeries with abdominal incisions lead to severe abdominal pain, which if treated inadequately, can cause shallow breathing, atelectasis, retention of secretions and lack of cooperation in physiotherapy. This increases the incidence of post-operative morbidity and leads to delayed recovery.Epidural anesthesia is safe and inexpensive technique with the advantage of providing surgical anesthesia and prolonged postoperative pain relief. It also an effective treatment of operative pain blunts autonomic, somatic and endocrine responses. Morphine and midazolam can be used as adjuvant to bupivicain to reduced the postoperative pain

Enrollment: 20 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II patients scheduled for major abdominal cancer surgeries

Exclusion criteria

• patients with known allergy to the study drugs,
• significant cardiac, respiratory, renal or hepatic disease,
• drug or alcohol abuse,
• psychiatric illness that would interfere with perception and assessment of pain.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 3 patient groups

MI

Active Comparator group

Description:

Bupivacaine 0.25% + midazolam 5mg in total volume 10m1

Treatment:

Drug: midazolam

MM

Active Comparator group

Description:

Bupivacaine 0.25% + midazolam 5mg and morphine 5mg in total volume 10ml

Treatment:

Drug: midazolam

MO

Active Comparator group

Description:

bupivacaine 0.25% + morphine 5 mg in total volume 10 ml

Treatment:

Drug: midazolam