Combined HCC-MFCCC

University of Milan

Status: Completed

Conditions: Surgery; Hepatocellular Carcinoma; Liver Carcinoma; Cholangiocarcinoma

Treatments: Procedure: Hepatectomy

Study type: Observational

Funder types: Other

Identifiers

NCT03178409

cHCC-MFCCC

Details and patient eligibility

About

Combined hepatocellular and mass-forming cholangiocarcinoma (cHCC-MFCCC) is a rare tumor. The aim of this study was the analysis of the outcome comparing such tumor with classic hepatocellular carcinoma (HCC) and mass-forming cholangiocarcinoma (MFCCC).

Full description

The institutional prospectively maintained database was queried, and 20 patients with cHCC-MFCCC were identified. A 2:1 match was performed with 40 patients operated in the same period for HCC, and with 40 operated for MFCCC. Only T1 or T2 patients N0 M0 were considered. Primary endpoint was the overall survival (OS) and disease-free survival (DFS).

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• positive histology for cHCC-MFCCC, HCC, and MFCCC
• complete clinical, surgical, pathological and follow-up data.

Exclusion criteria

• patients preoperatively treated with chemotherapy, radiofrequency ablation or trans-arterial therapies were excluded.
• patients operated for recurrent disease and/or with non-radical surgery
• patients with missing data were also excluded

Trial design

100 participants in 3 patient groups

cHCC-MFCCC

Description:

Patients affected by combined HCC-MFCCC

Treatment:

Procedure: Hepatectomy

HCC

Description:

Patients affected by classical HCC

Treatment:

Procedure: Hepatectomy

MFCCC

Description:

Patients affected by classical MFCCC

Treatment:

Procedure: Hepatectomy