Combined High-Intensity Aerobic Training and Resistance Training in Psoriatic Arthritis (PsA-HIIT)

Vastra Gotaland Region

Status: Not yet enrolling

Conditions: Psoriatic Arthritis

Treatments: Behavioral: Exercise program

Study type: Interventional

Funder types: Other

Identifiers

NCT07352696

Vastra Gotaland record 286312

Details and patient eligibility

About

The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and inflammation in patients with Psoriatic arthritis. A secondary goal is to assess the intervention´s impact on physical fitness, pain, fatigue, and health-related quality of life, and to explore long-term maintenance of exercise following completion of the intervention. We hypothesize that 12 weeks of combined high-intensity interval aerobic training and strength training will improve cardiometabolic health, inflammation, and enhance physical fitness, fatigue, pain and quality of life in Psoriatic arthritis.

Enrollment: 88 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Psoriatic arthritis disease according to the CASPAR (Classification Criteria for Psoriatic Arthritis) criteria
• Age range 18-65 years
• Stable medication on anti- rheumatic drugs for >3 months prior to inclusion and throughout the first 3 months of the study

Exclusion criteria

• Cardiovascular disease
• Severe hypertension
• Diabetes type I
• Chronic obstructive pulmonary disease or other severe pulmonary diseases
• Arthroplasty of large joints, lower extremities
• Severe functional impairment precluding participation in high-intensity aerobic exercise
• Inability to perform a cardiopulmonary exercise testing (CPET)
• Pregnancy
• BMI ≥35 kg/m²
• Ongoing or planned initiation (within 3 months) of structured weight reduction therapy, pharmacological obesity treatment, or bariatric bypass surgery
• Already participating in regular exercise at high intensity (BORG ≥15) for >1 hour/ week during the past 6 months
• Inability to understand and read Swedish

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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88 participants in 2 patient groups

Exercise group

Experimental group

Description:

Cardiorespiratory and strength training, 2-3 sessions per week for a total of 12 weeks.

Treatment:

Behavioral: Exercise program

Control group

No Intervention group

Description:

Care as usual, plus individualized counseling for health-promoting physical activity