Combined Nutrient Intake and Muscle Protein Synthesis

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Aging

Treatments: Other: protein; Other: protein and leucine; Other: protein and carbohydrate

Study type: Interventional

Funder types: Other

Identifiers

NCT01239277

MEC 10-3-080

Details and patient eligibility

About

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Enrollment: 48 patients

Sex: Male

Ages: 70 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• males
• 70-85 years or 18-30 years
• BMI < 30

Exclusion criteria

• Type II diabetes
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs
• Use of anticoagulants
• Patients suffering from Phenylketonuria
• Participation in any regular exercise programme

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 4 patient groups

protein (elderly)

Experimental group

Treatment:

Other: protein

protein and carbohydrate (elderly)

Experimental group

Treatment:

Other: protein and carbohydrate

protein and carbohydrate (young)

Experimental group

Treatment:

Other: protein and carbohydrate

protein and leucine (elderly)

Experimental group

Treatment:

Other: protein and leucine