Combined Procedures in the Treatment of Severe Acne Scars

Al-Azhar University

Status and phase: Not yet enrolling; Phase 2

Conditions: Atrophic Acne Scar

Treatments: Procedure: Polydioxanone mono threads insertion; Procedure: Platelet rich plasma injection; Procedure: Scar subcision; Device: Fractional carbon dioxide laser

Study type: Interventional

Funder types: Other

Identifiers

NCT06227481

Severe acne scars

Details and patient eligibility

About

Many methods utilize for acne scar treatment including laser, cosmetic filler, microneedling, local tumescent, Subcision and chemical peels. These procedures can be used individually or as a combination therapy.

Combining procedures give better results. In our study we will try in the period from March 2024 to March 2026, to assess the efficacy of combination of scar subcision with platelet rich plasma, Polydioxanone mono threads or fractional Carbon dioxide laser in the treatment of severe atrophic acne scars with 1:1:1 ratios and to compare between these modalities regarding safety and efficacy.

Full description

This is a prospective controlled trial that will be conducted at Dermatology, venereology, and andrology Department, Al-Azhar university hospital, Assiut, in the period from March 2024 to March 2026, to assess the efficacy of combination of scar subcision with platelet rich plasma , polydioxanone mono threads or fractional carbon dioxide laser in the treatment of severe atrophic acne scars with 1:1:1 ratios and to compare between these modalities regarding safety and efficacy

Enrollment: 48 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with severe atrophic acne scars (as per Goodman and Baron's acne qualitative scar grading scale)

Exclusion criteria

• Patients with active acne lesions.
• Patients having a keloid formation tendency.
• Patients with a history of bleeding disorder or severe anemia.
• Pregnant or lactating women.
• Patients received any treatment for scars in the last 6 months.
• Patients using drugs causing photosensitivity or systemic retinoids in the previous 6 months (for laser group).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 3 patient groups

Subcision plus platelet rich plasma

Active Comparator group

Description:

3 sessions of scar subcision with platelet rich plasma injection at the same session with one month interval

Treatment:

Procedure: Platelet rich plasma injection

Procedure: Scar subcision

Subcision plus Polydioxanone mono threads

Active Comparator group

Description:

3 sessions of scar subcision followed by the insertion of Polydioxanone mono threads after the last session

Treatment:

Procedure: Polydioxanone mono threads insertion

Procedure: Scar subcision

Subcision plus fractional carbon dioxide laser

Active Comparator group

Description:

3 sessions of scar subcision with Fractional carbon dioxide laser at the same session with one month interval

Treatment:

Device: Fractional carbon dioxide laser

Procedure: Scar subcision