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Combined Procedures in the Treatment of Severe Acne Scars

A

Al-Azhar University

Status and phase

Not yet enrolling
Phase 2

Conditions

Atrophic Acne Scar

Treatments

Procedure: Polydioxanone mono threads insertion
Procedure: Platelet rich plasma injection
Procedure: Scar subcision
Device: Fractional carbon dioxide laser

Study type

Interventional

Funder types

Other

Identifiers

NCT06227481
Severe acne scars

Details and patient eligibility

About

Many methods utilize for acne scar treatment including laser, cosmetic filler, microneedling, local tumescent, Subcision and chemical peels. These procedures can be used individually or as a combination therapy.

Combining procedures give better results. In our study we will try in the period from March 2024 to March 2026, to assess the efficacy of combination of scar subcision with platelet rich plasma, Polydioxanone mono threads or fractional Carbon dioxide laser in the treatment of severe atrophic acne scars with 1:1:1 ratios and to compare between these modalities regarding safety and efficacy.

Full description

This is a prospective controlled trial that will be conducted at Dermatology, venereology, and andrology Department, Al-Azhar university hospital, Assiut, in the period from March 2024 to March 2026, to assess the efficacy of combination of scar subcision with platelet rich plasma , polydioxanone mono threads or fractional carbon dioxide laser in the treatment of severe atrophic acne scars with 1:1:1 ratios and to compare between these modalities regarding safety and efficacy

Enrollment

48 estimated patients

Sex

All

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

• Patients with severe atrophic acne scars (as per Goodman and Baron's acne qualitative scar grading scale)

Exclusion criteria

  • Patients with active acne lesions.
  • Patients having a keloid formation tendency.
  • Patients with a history of bleeding disorder or severe anemia.
  • Pregnant or lactating women.
  • Patients received any treatment for scars in the last 6 months.
  • Patients using drugs causing photosensitivity or systemic retinoids in the previous 6 months (for laser group).

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

48 participants in 3 patient groups

Subcision plus platelet rich plasma
Active Comparator group
Description:
3 sessions of scar subcision with platelet rich plasma injection at the same session with one month interval
Treatment:
Procedure: Platelet rich plasma injection
Procedure: Scar subcision
Subcision plus Polydioxanone mono threads
Active Comparator group
Description:
3 sessions of scar subcision followed by the insertion of Polydioxanone mono threads after the last session
Treatment:
Procedure: Polydioxanone mono threads insertion
Procedure: Scar subcision
Subcision plus fractional carbon dioxide laser
Active Comparator group
Description:
3 sessions of scar subcision with Fractional carbon dioxide laser at the same session with one month interval
Treatment:
Device: Fractional carbon dioxide laser
Procedure: Scar subcision

Trial contacts and locations

0

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Central trial contact

Ahmed O Hassan

Data sourced from clinicaltrials.gov

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