Combining Behavioral Treatment With Agonist Maintenance - 1

Yale University

Status and phase: Completed; Phase 3

Conditions: Opioid-Related Disorders; Substance-Related Disorders; Cocaine-Related Disorders

Treatments: Drug: methadone; Drug: Buprenorphine

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000311

NIDA-09413-1

R01DA009413 (U.S. NIH Grant/Contract)

R01-09413-1

Details and patient eligibility

About

The purpose of this study is to evaluate whether the community reinforcement approach (CRA) plus contingency management (CM) is more effective overall than CRA only in reducing illicit opioid and cocaine use during agonist maintenance treatment and at 3 and 6 month follow-up after completion of study protocol, and to compare the efficacy of maintenance on buprenorphine to methadone when maintenance is combined with CRA only or CRA plus CM.

Enrollment: 168 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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168 participants in 4 patient groups

1

Experimental group

Description:

Methadone + CM (contingency management)

Treatment:

Drug: methadone

2

Experimental group

Description:

methadone + VC (voucher control)

Treatment:

Drug: methadone

3

Experimental group

Description:

Buprenorphine + CM

Treatment:

Drug: Buprenorphine

4

Experimental group

Description:

Buprenorphine + VC

Treatment:

Drug: Buprenorphine