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This work will extend and apply methods for modeling heterogeneous treatment effects when multiple studies are available, with a particular focus on the complexities in mental health research. The methods will be illustrated in examples estimating the effects of medical treatments for major depressive disorder (duloxetine and vortioxetine) using 4 randomized controlled trials (available in the Vivli trials resource) and non-experimental data from the Duke University Health System electronic health record and the Johns Hopkins Health System electronic health record systems.
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Duke University Health System Electronic Health Record (EHR) System and Johns Hopkins Health System EHR System
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Exclusion criteria:
4 randomized controlled trials (RCTs)
Inclusion criteria:
9,586 participants in 6 patient groups
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Data sourced from clinicaltrials.gov
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