Combining Erlotinib Plus Bevacizumab and Gemcitabine Plus Capecitabine to Treat Advanced Pancreatic Cancer (TARGET)

Royal Marsden NHS Foundation Trust

Status and phase

Completed

Phase 2

Phase 1

Conditions

Pancreatic Cancer

Treatments

Drug: Gemcitabine 1000 mg/m2 iv days 1, 8, 15 of a 28 day cycle

Drug: Capecitabine orally days 1 -21

Drug: Bevacizumab 5 mg/kg intravenously every 2 weeks

Drug: Erlotinib 100 mg orally days 1-28

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00260364

EudraCT No.: 2005-002715-24

CCR2631

Details and patient eligibility

About

Pancreatic cancer is an aggressive, largely chemo-resistant disease with a poor prognosis. EGFR and VEGF are both overexpressed in pancreatic cancers and thought to contribute to tumour development and progression. The combination of gemcitabine and capecitabine has recently been shown to be effective in advanced pancreatic cancer. The combination of gemcitabine plus erlotinib has also been shown to be effective in advanced pancreatic cancer. The aim of this study is to assess whether combining a chemotherapy doublet (gemcitabine plus capecitabine) and a biologic doublet (erlotinib plus bevacizumab) is a safe and effective way to treat advanced pancreatic cancer by targeting multiple tumour stimulating mechanisms simultaneously.

Full description

To establish the safety and efficacy of a combination of four drugs (capecitabine, gemcitabine, erlotinib and bevacizumab) in the treatment of patients with locally advanced or metastatic pancreatic cancer. The study will be divided into two parts:

Part A (Phase I ): Is to establish the optimal dose of capecitabine for combination with gemcitabine, bevacizumab and erlotinib. This part of the study is necessary in order to characterise any increased side effects that may occur as a result of this combination of drugs. The dose of capecitabine will be increased in cohorts containing 3 to 6 patients(according to standard dose escalation study design) whilst side effects are closely monitored. The doses of the other three drugs will remain fixed during this period:

Gemcitabine: 1000 mg/m2 Days 1, 8, 15
Bevacizumab: 5 mg/kg every two weeks iv
Erlotinib: 100 mg/day orally

Maximum tolerated dose is the dose at which 2 out of a cohort of three to six patients experience dose-limiting toxicity within the first cycle (28 days) of treatment. The recommended dose for further evaluation will be one dose level below this.

Part B (Phase II): Once a recommended dose of capecitabine has been chosen, this will be used for the remainder of the trial to further characterise the efficacy and safety of the drug combination in this group of patients.

Enrollment

44 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Histologically or cytologically confirmed adenocarcinoma of the pancreas
Locally advanced or metastatic disease
Not amenable to curative resection
No invasion of adjacent organs (e.g., duodenum or stomach) by CT scan
Unidimensionally measurable disease as assessed by CT in accordance with the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines.
No evidence of brain metastasis

PATIENT CHARACTERISTICS:

Age:

18 and over

Performance status:

Eastern Cooperative Oncology Group (ECOG) 0-2

Life expectancy:

Greater than 3 months

Hematopoietic:

Granulocyte count ≥ 1,500/mm^3
Platelet count ≥ 100,000/mm^3

Hepatic:

Bilirubin ≤ upper limit of normal
Serum albumin > 26 g/litre

Renal:

Creatinine ≤ 180 micromoles/litre OR
Creatinine clearance ≥ 50 mL/min

Cardiovascular:

No clinically significant cardiovascular disease
No uncontrolled hypertension (i.e., blood pressure > 150/90 mm Hg on medication)
No arterial thromboembolic event within the past 6 months, including any of the following:
- Myocardial infarction
- Unstable angina pectoris
- Cerebrovascular accident
- Transient ischemic attack
No New York Heart Association grade II-IV congestive heart failure
No serious cardiac arrhythmia requiring medication

OTHER:

Not pregnant or breast feeding
Fertile patients must use effective contraception during study participation
No serious or non-healing wound, ulcer, or bone fracture
No infection requiring parenteral antibiotics
No major bleeding diathesis or coagulopathy
No significant traumatic injury within the past 28 days
No surgery within the last 28 days or anticipation for the need for major surgery during the course of study treatment
No other active malignancy except non-melanoma skin cancer and cervical cancer in-situ
No history of known dihydropyrimidine dehydrogenase (DPD) deficiency
No lack of physical integrity of the upper gastro-intestinal tract, malabsorption syndrome, or inability to take oral medication

PRIOR CONCURRENT THERAPY:

No previous chemotherapy, radiotherapy or other investigational drug treatment for metastatic disease (including VEGF or EGFR antagonists)
No previous preoperative or adjuvant chemotherapy, radiotherapy or other investigational drug treatment.
No full dose anti-coagulation (i.e. warfarin or full dose low molecular weight heparin) prior to starting study treatment.
No ongoing treatment with aspirin (>325 mg/day) or other medications known to predispose to gastrointestinal ulceration