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The main objective is to compare the accuracy of transient elastography taking into account liver steatosis determined by MRI, to liver biopsy for the diagnosis of liver fibrosis ≥F2 in patient with NAFLD.
Full description
No alcoholic fatty liver disease (NAFLD) is induced by an abnormal build up of fat in the liver. It can induce liver damage, namely fibrosis, which leads to cirrhosis and an increased risk of liver cancer. The diagnosis of liver fibrosis is thus critical to identify patients at risk.
Liver biopsy is the gold standard for the diagnosis of liver fibrosis. However this invasive test is expensive and has a significant morbidity.
To avoid this others non invasive test have been developed to assess steatosis and fibrosis of the liver :
The hypothesis driving this study is that by accounting for liver steatosis through the mean of MRI, we could more accurately interpret transient elastography value to accurately diagnose the severity of liver fibrosis.
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Inclusion criteria
Patients older than 18 years old
For which a liver biopsy is indicated for NAFLD according to current guidelines
Presenting with at least one of the metabolic syndrome criteria:
Affiliated to medical care insurance
Having signed informed consent for participating in the study
Exclusion criteria
270 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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