Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Northwestern University

Status: Enrolling

Conditions: Stroke

Treatments: Other: Targeted Memory Reactivation (TMR)

Study type: Interventional

Funder types: Other

Identifiers

NCT04312269

SP0052149

Details and patient eligibility

About

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.

Enrollment: 70 estimated patients

Sex: All

Ages: 21 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age at enrollment is 21 or older
• Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
• Severe to moderate motor impairment (FMA-UE of 7-40)
• At least some voluntary shoulder and elbow muscle activation

Exclusion criteria

• Inability to follow instructions of the MyoCI task
• Visual impairment (such as hemianopia) preventing full view of screen
• Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
• Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
• Inability to understand or follow commands in English due to aphasia or other reason
• Diffuse or multifocal infarcts in both hemispheres
• Substantial arm pain preventing participation for 90 minutes a day
• Spasticity treatment (pharmacological or Botox) within last 3 months
• Ferromagnetic implants that are MRI incompatible

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 4 patient groups

All phase TMR

Experimental group

Description:

TMR during every stage of sleep

Treatment:

Other: Targeted Memory Reactivation (TMR)

Slow-wave sleep (SWS) only TMR

Experimental group

Description:

TMR during slow-wave sleep only

Treatment:

Other: Targeted Memory Reactivation (TMR)

Reduced frequency TMR

Experimental group

Description:

TMR during only subset of sessions

Treatment:

Other: Targeted Memory Reactivation (TMR)

Sham TMR

Sham Comparator group

Description:

Patients receive no TMR

Treatment:

Other: Targeted Memory Reactivation (TMR)