Combining PAS to Non-invasive VNS

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Spinal Plasticity

Treatments: Device: VNS; Device: PAS

Study type: Interventional

Funder types: Other

Identifiers

NCT04938284

UAK1022001

Details and patient eligibility

About

Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively. Here we will investigate in healthy subjects the synergistic effect of these stimulation modalities on motor-evoked potential (MEP) potentiation.

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria:

• contraindications to TMS (e.g. brain pathology, implanted devices)
• contraindications to MRI (e.g. MRI incompatible implants)
• continuous use of CNS-active drugs
• neurological, psychiatric or cardiovascular disease
• drug abuse

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 4 patient groups

PAS and VNS

Experimental group

Treatment:

Device: PAS

Device: VNS

PAS and sham VNS

Active Comparator group

Treatment:

Device: PAS

PAS

Active Comparator group

Treatment:

Device: PAS

VNS

Active Comparator group

Treatment:

Device: VNS