Communicating Human Papillomavirus Vaccine With Japanese Parents and Caregivers With Daughters Aged 12-18

The University of Hong Kong (HKU)

Status: Invitation-only

Conditions: Healthy

Treatments: Behavioral: Group 11 (I x E x D x F); Behavioral: Group 10 (O x S x D x F); Behavioral: Group 9 (I x S x D x F); Behavioral: Group 8 (O x E x S x M); Behavioral: Group 13 (I x S x D x M); Behavioral: Group 7 (I x E x S x M); Behavioral: Group 4 (O x E x S x F); Behavioral: Group 1 (I x S x S x F); Behavioral: Group 15 (I x E x D x M); Behavioral: Group 6 (O x S x S x M); Behavioral: Group 2 (O x S x S x F); Behavioral: Group 12 (O x E x D x F); Behavioral: Group 14 (O x S x D x M); Behavioral: Group 5 (I x S x S x M); Behavioral: Group 3 (I x E x S x F); Behavioral: Group 16 (O x E x D x M)

Study type: Interventional

Funder types: Other

Identifiers

NCT06347627

UW23139

Details and patient eligibility

About

This study aims to comprehensively assess confidence in and acceptance of human papillomavirus (HPV) vaccines among Japanese parents and caregivers with daughters aged 12-18 and their decision-making process.

Full description

This study will implement an experiment as a sixteen-arm randomized controlled trial in an online survey environment. Before the experiment, participants, who are Japanese caregivers with daughters aged 12-18 who have not received an HPV vaccine, will first answer a pre-experiment survey. The survey will collect information on participants' socio-demographic data and key decision-making factors for HPV vaccine acceptance and confidence. Then, the study will randomly assign the participants to view one digital communication message using a 2 × 2 × 2 × 2 between-person factorial experiment on 'components of message.' The sixteen experimental messages will be developed based on real social media messages posted between November 2021 and April 2022, when the Japanese government prepared to reinstate an active recommendation of HPV vaccines for eligible girls after eight and a half years of suspension.

The sixteen messages will assess four factors: messenger, style, content, and misinformation. Each message will be similar except for one variable in consideration. The messenger component will be whether the message is from an individual or an organization. As individual messengers, the study will set a fictional male or female with common Japanese names who actively communicate about HPV vaccines. As organizational messengers, the study will use the existing accounts of the Ministry of Health, Labour and Welfare or the Japan Cancer Society or a fictional account of an anti-vaccine group. The style component will be whether the message conveys information through storytelling or scientific data. Messages will include personal stories for the storytelling style and statistics for the scientific data style. The content component will be whether the message conveys information about the effectiveness of the HPV vaccine in preventing diseases or the safety of the HPV vaccine. The contents will be built on both factual information and misconceptions about HPV vaccine safety and effectiveness that are often mentioned in the actual social media posts. The misinformation component will be whether the message conveys misinformation or factual information. The study will debrief all respondents exposed to misinformation after the survey.

Lastly, the study will collect data as a post-experiment survey to evaluate how an online message influenced caregivers' trust, confidence, and motivation to vaccinate.

Enrollment: 1,600 estimated patients

Sex: Female

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female adult caregivers, older than 20, with daughters aged 12-18 who have received none or only one shot of HPV vaccine.

Exclusion criteria

• Caregivers who do not agree to participate in survey, experiment, or both.
• Caregivers with daughters who have already received two or more HPV vaccines.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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1,600 participants in 16 patient groups

Group 1 (I x S x S x F)

Experimental group

Description:

Participants in Group 1 will view a message in an X (former Twitter) format composed of "Individual x Safety x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 1 (I x S x S x F)

Group 2 (O x S x S x F)

Experimental group

Description:

Participants in Group 2 will view a message in an X (former Twitter) format composed of "Organization x Safety x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 2 (O x S x S x F)

Group 3 (I x E x S x F)

Experimental group

Description:

Participants in Group 3 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 3 (I x E x S x F)

Group 4 (O x E x S x F)

Experimental group

Description:

Participants in Group 4 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 4 (O x E x S x F)

Group 5 (I x S x S x M)

Experimental group

Description:

Participants in Group 5 will view a message in an X (former Twitter) format composed of "Individual x Safety x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 5 (I x S x S x M)

Group 6 (O x S x S x M)

Experimental group

Description:

Participants in Group 6 will view a message in an X (former Twitter) format composed of "Organization x Safety x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 6 (O x S x S x M)

Group 7 (I x E x S x M)

Experimental group

Description:

Participants in Group 7 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 7 (I x E x S x M)

Group 8 (O x E x S x M)

Experimental group

Description:

Participants in Group 8 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 8 (O x E x S x M)

Group 9 (I x S x D x F)

Experimental group

Description:

Participants in Group 9 will view a message in an X (former Twitter) format composed of "Individual x Safety x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 9 (I x S x D x F)

Group 10 (O x S x D x F)

Experimental group

Description:

Participants in Group 10 will view a message in an X (former Twitter) format composed of "Organization x Safety x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 10 (O x S x D x F)

Group 11 (I x E x D x F)

Experimental group

Description:

Participants in Group 11 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 11 (I x E x D x F)

Group 12 (O x E x D x F)

Experimental group

Description:

Participants in Group 12 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 12 (O x E x D x F)

Group 13 (I x S x D x M)

Experimental group

Description:

Participants in Group 13 will view a message in an X (former Twitter) format composed of "Individual x Safety x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 13 (I x S x D x M)

Group 14 (O x S x D x M)

Experimental group

Description:

Participants in Group 14 will view a message in an X (former Twitter) format composed of "Organization x Safety x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 14 (O x S x D x M)

Group 15 (I x E x D x M)

Experimental group

Description:

Participants in Group 15 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 15 (I x E x D x M)

Group 16 (O x E x D x M)

Experimental group

Description:

Participants in Group 16 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.

Treatment:

Behavioral: Group 16 (O x E x D x M)