Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis

Olive View-UCLA Education & Research Institute

Status: Completed

Conditions: Pyelonephritis

Treatments: Other: No intervention

Study type: Observational

Funder types: Other; Other U.S. Federal agency; Industry

Identifiers

NCT01641029

11H-770351

Details and patient eligibility

About

Pyelonephritis is a serious infection that manifests with fever, back pain, nausea, and vomiting. In the U.S., it is estimated that there are 20 cases of pyelonephritis per 10,000 annually, with the highest incidence in young women. Escherichia coli (E. coli) causes over 80% of these infections. Over the last two decades, E. coli resistance has emerged to commonly prescribed antimicrobials, such as ampicillin and trimethoprim-sulfamethoxazole (TMP/SMX). Most recently, resistance to fluoroquinolones and strains producing extended-spectrum beta-lactamases (ESBL) have been observed. In order to better understand the evolution and current state of antibiotic resistance among E. coli urinary tract isolates so as to better inform treatment decisions, the investigators propose to conduct an investigation to: a) determine the prevalence of antimicrobial resistance among E. coli causing acute pyelonephritis in various patient groups, and specifically healthy community-dwellers with uncomplicated infections, b) determine the specific prevalence of fluoroquinolone-resistance and ESBL-producing E. coli, and c) determine potential risk factors for fluoroquinolone and ESBL-producing E. coli infections.

Enrollment: 720 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients > 18 years of age with flank pain and/or costovertebral angle tenderness
• documented temperature in the emergency department of ≥38°C/100.4°F by any method of measurement,
• documented temperature in the emergency department of ≥38°C/100.4°F by any method of measurement,

Exclusion criteria

• complicated pyelonephritis

Trial design

720 participants in 1 patient group

pyelonephritis

Description:

Patients \> 18 years of age with flank pain and/or costovertebral angle tenderness, documented temperature in the emergency department of ≥38°C/100.4°F by any method of measurement, and clinically suspected acute pyelonephritis. Patients will be identified by their emergency department treating physicians.

Treatment:

Other: No intervention