Comorbid Chronic Lung Disease on Heart Failure

Chang Gung Medical Foundation

Status: Completed

Conditions: Comorbid Chronic Lung Disease on Heart Failure

Treatments: Diagnostic Test: cardiopulmonary exercise test

Study type: Observational

Funder types: Other

Identifiers

NCT04141345

201701459B0

Details and patient eligibility

About

Comorbid chronic lung disease (CLD) increases mortality in heart failure (HF) patients. Understanding the predictors and pathophysiology of HF can improve the efficacy of HF treatment. This study evaluated the cardiopulmonary exercise test (CPET) results to identify significant predictors on long-term outcomes in HF patients with CLD.

Full description

The CPET was administered in a cohort of 169 HF outpatients with exercise intolerance at a tertiary referral center between May 2007 and July 2010. A CLD was defined as abnormal spirometry accompanied by clinical symptoms and signs included in the Global Initiative for Chronic Obstructive Lung Disease criteria. The primary endpoint was defined as CV mortality or the first HF hospitalization. Totally 49 events occurred before the end of follow up in January 2018.

Enrollment: 169 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• outpatients ≥ 18 years of age, male or female.
• Patients with a diagnosis of heart failure with clinical symptoms and echocardiography evidence
• Patients received cardiopulmonary exercise test exams

Exclusion criteria

• Cannot tolerance exercise test due to muscular-skeletal disorder
• Cannot co-operate all functional studies
• Family reject to participate in this project

Trial design

169 participants in 2 patient groups

Heart failure with chronic lung disease

Description:

Patients were recruited consecutively based on clinical assessment of risk factors for HF and echocardiographic evidence of systolic dysfunction or diastolic dysfunction. Risk factors for HF were defined as hypertension, atherosclerotic disease, obesity, chronic obstructive lung disease, metabolic syndrome, smoking, and family history of HF. In patients with normal LVEF (\<50), diagnosis of diastolic dysfunction was based on echocardiographic parameters. Chronic lung disease (CLD) was defined as spirometry with obstructive lung disease or restrictive lung disease with accompanying clinical symptoms and signs included in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.

Treatment:

Diagnostic Test: cardiopulmonary exercise test

Heart failure without chronic lung disease

Description:

Patients were recruited consecutively based on clinical assessment of risk factors for HF and echocardiographic evidence of systolic dysfunction or diastolic dysfunction. Risk factors for HF were defined as hypertension, atherosclerotic disease, obesity, chronic obstructive lung disease, metabolic syndrome, smoking, and family history of HF. In patients with normal LVEF (\<50), diagnosis of diastolic dysfunction was based on echocardiographic parameters. Chronic lung disease (CLD) was defined as spirometry with obstructive lung disease or restrictive lung disease with accompanying clinical symptoms and signs included in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. HF patients who did not have chronic lung disease were assigned as a non-CLD group.

Treatment:

Diagnostic Test: cardiopulmonary exercise test