Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis

Chinese PLA General Hospital (301 Hospital)

Status: Unknown

Conditions: Enthesopathy

Treatments: Device: Musculoskeletal Ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT02962271

ChinaPLAGH-PsA

Details and patient eligibility

About

Psoriatic arthritis(PsA) and psoriasis(Ps) are two systemic inflammatory diseases linked with rash of psoriasis, but there's still great controversy regarding the exact relationship between them. Our study is to investigate the characteristics and differences of the ultrasonic imaging of enthesopathy in the lower extremity in patients with PsA and Ps, to explore the risk factors of Ps developing into PsA in the long term course.

Full description

As one of the most common chronic inflammatory skin diseases, psoriasis(Ps) can be intimately associated to psoriatic arthritis (PsA), affecting approximately 1% to 2% of the world's population. About 30% of them will develop into PsA with serious impact on their health-related quality of life.

PsA, characterised by different subsets with varying degree of severity, is a chronic, complicated inflammatory disease.Enthesitis is the prevalent and distinctive feature of PsA.

Musculoskeletal Ultrasound (MSUS) is a valid noninvasive modality, essential to evaluate entheses thickness, enthesophytes, bursitis and bone erosions as well as to disclose vascularisation on tendons through power doppler (PD) assessment. In recent years, more and more attention has been paid to the diagnosis and management of Ps and PsA, owing to its discrimination of identifying subclinical entheses and joint changes.

Enrollment: 187 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis or osteoarthritis.
• Body Mass Index (BMI)<30 kg/m2.
• Absence of local glucocorticoid or other drugs injection or surgical treatment for entheses scanned in the previous 6 weeks prior to clinical and musculoskeletal ultrasound (MSUS) evaluation.

Exclusion criteria

• Other systemic rheumatic diseases or malignant neoplasms.
• Peripheral neuropathy of lower extremity.

Trial design

187 participants in 2 patient groups

Psoriatic Arthritis

Description:

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Treatment:

Device: Musculoskeletal Ultrasound

Psoriasis

Description:

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Treatment:

Device: Musculoskeletal Ultrasound