Comparative Effect of Theipoental and Propofol in IVF Outcome

Aristotle University Of Thessaloniki

Status and phase: Completed; Phase 4

Conditions: Subfertility

Treatments: Drug: Propofol; Drug: Thiopental

Study type: Interventional

Funder types: Other

Identifiers

NCT02377778

UHR-8

Details and patient eligibility

About

In this study the aim is to compare the effect of the type of anaesthetic drug used during oocyte retrieval on fertilization rates of oocytes retrieved after ovarian stimulation for in-vitro fertilization.

Enrollment: 180 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women undergoing oocyte retrieval for IVF under general anesthesia
• age ≤45 years

Exclusion criteria

• women with a known hypersensitivity to the active substance of the investigating drugs or any of their excipients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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180 participants in 2 patient groups

Propofol

Experimental group

Description:

In this arm patients will be receiving propofol for anaesthesia at doses 3-5mg depending on the time needed to complete oocyte retrieval

Treatment:

Drug: Propofol

Thiopental

Active Comparator group

Description:

In this arm patients will receive thiopental for anaesthesia at doses 7mg and a repeat dose of 2-3mg depending on the time needed to completed oocyte retrieval

Treatment:

Drug: Thiopental