Comparative Effects of CGF and PRP in Impacted Third Molar Surgery

Recep Tayyip Erdogan University

Status: Completed

Conditions: Impacted Third Molar

Treatments: Biological: Platelet-Rich Plasma (PRP); Biological: Concentrated Growth Factor (CGF)

Study type: Interventional

Funder types: Other

Identifiers

NCT07320170

2024/52

Details and patient eligibility

About

This study evaluates the effects of two different blood products obtained from the patient's own blood (Concentrated Growth Factor [CGF] and Platelet-Rich Plasma [PRP]) on healing after wisdom tooth extraction. The aim is to determine whether applying these materials to the extraction area reduces postoperative pain, facial swelling, and the risk of dry socket compared to standard healing.

Full description

This prospective, randomized, controlled clinical trial compares the efficacy of autologous platelet concentrates in reducing postoperative sequelae following the surgical extraction of impacted mandibular third molars.

A total of 42 patients were randomly assigned to one of three groups:

Control Group: Standard surgical extraction without additional biomaterials.

CGF Group: Standard extraction followed by the placement of a CGF clot into the extraction socket.

PRP Group: Standard extraction followed by submucosal injection of PRP.

The primary outcome measured is postoperative pain (Visual Analog Scale) on postoperative days 1, 3, and 7. The secondary outcomes include facial swelling (linear measurements) on postoperative days 1, 3, and 7, and the incidence of alveolar osteitis (dry socket).

Enrollment: 42 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged between 18 and 50 years.
• Systemically healthy individuals classified as American Society of Anesthesiologists (ASA) Class I or Class II.
• Presence of impacted mandibular third molars (teeth 38 and 48 according to Fédération Dentaire Internationale (FDI) notation).
• Mesioangular impaction with bone retention according to Winter's classification.
• Class II relationship to the ramus according to the Pell and Gregory classification.
• Level B or Level C depth of impaction according to the Pell and Gregory classification.

Exclusion criteria

• Patients younger than 18 years.
• Habitual smoking or alcohol consumption.
• Presence of coagulation (bleeding) disorders.
• Systemic diseases affecting wound healing or use of medications that compromise healing.
• Pregnancy or lactation.
• Presence of active pericoronitis associated with the tooth.
• Presence of pathological lesions (cysts or tumors) associated with the impacted tooth.
• Uncontrolled periodontal disease in the oral cavity.
• Known allergy to any medications used in the study protocol.
• Inability to comply with follow-up visits.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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42 participants in 3 patient groups

Control Group

No Intervention group

Description:

Standard surgical extraction was performed without the application of any additional biomaterials.

CGF Group

Experimental group

Description:

Standard surgical extraction followed by the placement of a Concentrated Growth Factor (CGF) clot into the extraction socket.

Treatment:

Biological: Concentrated Growth Factor (CGF)

PRP Group

Experimental group

Description:

Standard surgical extraction followed by submucosal injection of Platelet-Rich Plasma (PRP).

Treatment:

Biological: Platelet-Rich Plasma (PRP)